Lankalapalli Srinivas

Publications

• Research Article   
  Preparation and characterization of Eudragit L30 D-55, L100 and S100 coated Montelukast sodium pellets for chronotherapy: A possible relevance to therapeutic targets
  Author(s): Ponnaganti SS Prasanna Kumar and Lankalapalli Srinivas*
  
  Objective: The initial research investigation on the current research work was to design, develop oral formulation of Pulsatile Drug Delivery Systems (PDDS) for Montelukast sodium with aim of treatment for asthma and designed as Pellets type of system with immediate and extended release of drug occurs after the lag time period. In chronic asthma condition patients suffered during the early morning hours (04.00 am to 06.00 am) so immediate release dosage forms are not suitable but the modified release formulation that is given at bed time and releases the drug as pulsed manner despite to wake up the patient. Methods: In this present investigation, Montelukast sodium pellets were prepared using Fluidized Bed Processor (FBP), seal coating with HPMC E5 and enteric coatings with Eudragit L30 D-55, Eudragit L100 and Eudragit S100 polymers for exte.. Read More»
  

  Abstract PDF