Jae-cheong Lim

Radioisotope Research Division, Quantum and Convergence Sciences, Korea Atomic Energy Research Institute, Republic of Korea

Publications

• Research Article   
  44/47 Scandium labelled cholecystokinin derivative for cancer theragnostics
  Author(s): Eun-ha Cho*, Jae-cheong Lim, So-young Lee and Ul-jae Park
  
  The Cholecystokinin (CCK) receptors are known to overexpress in various types of tumors. Through a previous study, a cyclic CCK analogue, DOTA-[Nle]-cCCK, was confirmed to have high in vivo stability and the tumor target ability of DOTA-[Nle]- cCCK capable of binding to the CCK receptor was confirmed through Lu-177 labeling. In this study, DOTA-[Nle]-cCCK was labeled with the pair-isotope, Sc-44/47, to confirm a technology that possibly could be applicable to radiopharmaceutical. First, we confirmed that the CCK receptor was overexpressed in AR42J, a cancer cell overexpressed in cancer tissue, and measured the binding ability of the receptor and DOTA-[Nle]-cCCK. We established the labeling method of radioactive scandium, and we confirmed that the Sc-44 labeled DOTA-[Nle]-cCCK administered to mice remained mostly in the bladder within an hour. Cell experiments with Sc-47 labe.. Read More»
  DOI: 10.4172/1896-8961.16.S1.001

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