Dileep Kumar Garnipudi

Department of Pharmaceutical sciences, Associate Professor, Vikas Group of Institutions, Nunna, Vijayawada Rural, Andhra Pradesh, 521212, India, India

Publications

• Research Article   
  Formulation and Evaluation of Eribulin Cubosomes for the Treatment of Breast Cancer
  Author(s): S. Alexandar, Hari Veluru, Ramu Samineni, Kommu Pradeep, Ram Mohan Manda, Azmath Farhana and Dileep Kumar Garnipudi*
  
  Breast cancer remains one of the leading causes of cancer-related mortality in women worldwide. Eribulin, a microtubule inhibitor, has shown promising therapeutic effects against metastatic breast cancer. However, its clinical efficacy is often limited by poor aqueous solubility and systemic toxicity. The present study aims to develop and evaluate Eribulin-loaded cubosomes to enhance its bioavailability, targeted delivery, and therapeutic efficacy. Cubosomes, which are bicontinuous cubic phase nanoparticles, provide a unique nanostructured delivery system with enhanced drug encapsulation and controlled release properties. The formulated cubosomes were characterized for their particle size, zeta potential, entrapment efficiency, in vitro drug release, cytotoxicity, and in vivo pharmacokinetic studies. The results demonstrated that Eribulinloaded cubosomes exhibit sustained drug release.. Read More»
  

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