Varalaxmi. S
Professor, Department of Pharmaceutical Sciences, Mohan Babu University, Tirupati, Andhra Pradesh, IndiaPublications
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Research Article
DEVELOPMENT AND CHARACTERIZATION OF CUBOSOME-BASED NANOFORMULATIONS OF CURCUMIN FOR ENHANCED TARGETING AND TREATMENT OF MELANOMA
Author(s): Dileep Kumar Garnipudi and Varalaxmi. S*
Objective: This study aimed to develop and characterise curcumin-loaded Cubosome formulations for enhanced targeting and treatment of melanoma, improving curcumin's bioavailability and therapeutic effectiveness. Methods: Curcumin was encapsulated in cubosomes made of glyceryl monooleate (GMO) and Pluronic F-127. The formulations were optimized by evaluating particle size, zeta potential, entrapment efficiency, and in vitro release. Cytotoxicity was tested on A375 melanoma cells, and in vivo studies were performed on melanomabearing mice. Skin permeation was also assessed. Results: The optimized curcumin-loaded cubosomes had a particle size of 120 ± 2.5 nm, zeta potential of -30.1 ± 1.2 mV, and entrapment efficiency of 85.2%. In vitro, curcumin release was sustained, and cytotoxicity assays showed enhanced antiproliferative effects (IC50 = 2.3 μM). In vivo, signifi.. Read More»
Editors List
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RAOUi Yasser
Senior Medical Physicist
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Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
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Sudhakar Tummala
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
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Alphonse Laya
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
- Fava Maria Giovanna
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Citations : 650
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