Nehal K. Naga

Department of Pathology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt

Publications

• Research Article   
  Immunohistochemical expression of GATA3, CK5/6 and snail-1 in intrinsic subtypes of bladder carcinoma
  Author(s): Nehal K. Naga, Samir N. Mina, Ayman M. El-Saka, Safinaz H. El-Shorbagy and Alaa I. Amer*
  
  Background: GATA3 binding protein has been described as a diagnostic immunomarker for urothelial carcinoma with high sensitivity and specificity. The purpose of this study was the evaluation of immunohistochemical based molecular classification of bladder cancer employing GATA3 and CK5/6, the relation between different subtypes and the available prognostic parameters of bladder cancer, correlation of the immunohistochemical expression of Snail-1 with various types of bladder carcinoma. Expression of GATA3, CK5/6 and Snail-1 immunohistochemistry was assessed in 80 formalin fixed embedded in paraffin blocks from selected cases of UBC (Trans Urethral Resection of bladder tumour 62 and Radical Cystectomy 18 specimens). Results: GATA3 showed positive nuclear expression in 75% of urothelial carcinoma cases, while all the studied cases of squamous cell carcinoma, adenocarcinoma and the neuro.. Read More»
  

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