Mohammed Abd ALmalik

Institute of Genetic Engineering and Biotechnology for Postgraduate Studies, University of Baghdad, Baghdad, Iraq

Publications

• Review Article   
  Association of TGF-B1 gene expression with breast cancer risk in a sample of Iraqi women
  Author(s): Muhammad Muaed Yasser* and Mohammed Abd ALmalik
  
  Breast carcinoma is the most prevalent cancer-related cause of death in women, and metastasis is the main factor in morbidity. The total number of new cases of cancer in Iraq during the year 2019 was 35,864. TGF (Transforming Growth Factor) is a multifunctional cytokine whose abnormal expression is linked to cancer development and metastasis. The tumor growth factor TGF?β is a major component of Epithelial–Mesenchymal Transition (EMT), immune evasion, and metastasis during cancer progression. It is produced by a variety of cells within the Tumor Microenvironment (TME), and it is responsible for regulating the activity of cells in this milieu. TGF-b is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Then, focusing on cancer, we discuss the roles of.. Read More»
  

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