J. Borjac

Faculty of Science, Department of Biological Sciences, Beirut Arab University, Debbieh, Lebanon

Publications

  • Research Article   
    Protective effect of Sorafenib against 1,2-Dimethylhydrazine-induced colorectal cancer in Balb/c Mice
    Author(s): M. Al Hassan, M. Al Battal, J. Usta and J. Borjac*

    Colorectal Cancer (CRC) is the third leading cause of cancer death in the world whose incidence is progressively rising in developing nations. It is treated with both chemotherapeutic and immunotherapeutic agents. Sorafenib is a broad-spectrum multikinase inhibitor proven to be effective in treating different types of carcinoma, including liver, thyroid, renal, and breast cancers. This study aimed to investigate the effect of Sorafenib against 1,2-dimethylhydrazine (DMH)-induced CRC in mice. Mice were injected with DMH (20 mg/kg) over 12 weeks to induce the cancer. Mice were treated with Sorafenib (30 mg/Kg for 5 days). Colon tissues were examined by histological analysis, and gene expression level of key players involved in the Wnt signaling pathway were assessed using RT-PCR. Our results showed that Sorafenib restored the normal histology and structu.. Read More»

    Abstract PDF

Editors List

  • S.SREEDHAR

    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

Google Scholar citation report
Citations : 61

Onkologia i Radioterapia received 61 citations as per Google Scholar report

Onkologia i Radioterapia peer review process verified at publons
Indexed In
  • Scimago
  • SCOPUS
  • MIAR
  • Euro Pub
  • Google Scholar
  • Medical Project Poland
  • PUBMED
  • Cancer Index
  • Gdansk University of Technology, Ministry Points 20