El Hilali Hafssa

Publications

• Case Report   
  Durable Response to Ribociclib?Fulvestrant in Breast Cancer With Pancreatic Metastasis and Neuroendocrine Features: A Case Report
  Author(s): Nejjari Sara*, Keita Diango, Alem Mehdi, Oufrid Abir, El Hilali Hafssa, Chbihi Chaymae, El Hakym Samia, Aabboub Basma, Amaadour Lamiae, Oualla Karima, Benbrahim Zineb, Arifi Samia, Mayeur Didier and Mellas Nawfel
  
  Invasive breast carcinoma with neuroendocrine differentiation (BC-NED) is a rare and distinct subtype. The combination of a rare metastatic site like the pancreas and a rare tumor subtype, as seen in our patient, presents a unique clinical scenario. We report the case of a 53-year-old female who was initially treated in 2011 for an HR+/HER2+ invasive ductal carcinoma of the right breast. After receiving adjuvant therapy, the patient developed a lesion in the pancreatic head in February 2020. Histopathological analysis confirmed the presence of a carcinoma consistent with a breast origin, but with the emergence of a neuroendocrine component. Systemic treatment with ribociclib plus fulvestrant was initiated. The patient achieved a complete clinical and radiological metabolic response with this regimen, which has been maintained to date with good treatment tolerance. The prognosis for pa.. Read More»
  

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