Parimala O

Publications

• Research Article   
  Formulation, Optimization, and In Vitro Evaluation of Docetaxel-Loaded Cubosomes for Breast Cancer Therapy
  Author(s): Anil Kumar Y*, Parimala O, Dileep Kumar Garnipudi, Kommu Pradeep, Srikrishna Theerdhala, Angilicam Avinash, Y. Sirisha and A. Rajesh
  
  Breast cancer remains a leading cause of cancer-related morbidity and mortality among women worldwide. Docetaxel is a potent taxane used in breast cancer chemotherapy; however, its therapeutic application is limited by poor aqueous solubility, nonspecific distribution, formulation-related adverse effects, and systemic toxicity. The present study aimed to formulate and evaluate docetaxel- loaded cubosomes as a lipid-based nanocarrier system for improving drug delivery and anticancer activity. Cubosomes were prepared using glyceryl monooleate as the lipid phase and poloxamer 407 as the stabilizer through a top-down emulsification and sonication method. Formulation variables were optimized based on particle size, polydispersity index, zeta potential, entrapment efficiency, and drug-loading capacity. The physicochemical and structural characteristics of the optimized formulation were inve.. Read More»
  

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