Jaikumar Shanmugasundaram

Publications

• Research Article   
  Flavone & monohydroxy flavones on paclitaxel - induced peripheral neuropathy in mice: A prospective Oncotherapeutic study
  Author(s): Parimala Kathirvelu, Nithya Panneerselvam*, Vijaykumar Sayeli, Jagan Nadipelly, Jaikumar Shanmugasundaram and Viswanathan Subramanian
  
  Background: Flavonoids are naturally occurring compounds known for their antioxidant and anti-inflammatory activities. This study examined whether flavone and its monohydroxy derivatives could reduce peripheral neuropathy caused by paclitaxel, a widely used anticancer drug. Methods: Male Swiss albino mice were treated with flavone or monohydroxyflavones at doses of 50, 100 and 200 mg/kg. Neuropathic symptoms were evaluated using standard behavioural tests: von Frey filaments for mechanical sensitivity, the acetone test for cold response and the tail-immersion method for thermal pain. Results: Mice receiving paclitaxel developed clear signs of neuropathy. Treatment with flavones and their derivatives reduced these symptoms in a dose-dependent manner. Among the compounds tested, 5-hydroxyflavone produced the most pot.. Read More»
  

  Abstract PDF