DivyaTeja Pagidi

Publications

• Review Article   
  Exploring the Anticancer Potential of Justicia tranquebarensis L.f.: Mechanisms of Action, Phytochemicals, and Therapeutic Implications in Oncology and Radiotherapy
  Author(s): DivyaTeja Pagidi* and Hari Veluru
  
  Justicia tranquebarensis L.f., a tropical medicinal plant from the Acanthaceae family, has been traditionally used for its anti-inflammatory, antimicrobial, and analgesic properties. Recent studies highlight its potential as a source of bioactive compounds including flavonoids, alkaloids, terpenoids, saponins, and tannins with notable anticancer activities. Preclinical evidence demonstrates that these phytochemicals can induce apoptosis via intrinsic and extrinsic pathways, arrest the cell cycle at critical checkpoints, and inhibit metastasis by modulating matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), and related signaling pathways. In vitro and in vivo studies show that quercetin, kaempferol, trigonelline, and eugenol exert cytotoxic effects on multiple cancer cell lines and reduce tumor progression in animal models. Additionally, these compounds exhibi.. Read More»
  

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