Antonenko Svitlana

PhD, Institute of Molecular Biology and Genetics National Academy of Sciences, Ukraine

Publications

• Conference Proceeding   
  Mechanism of Bcr-Abl/GLG1 protein complex formation and its role in the pathogenesis of chronic myeloid leukemia
  Author(s): Antonenko Svitlana*
  
  Statement of the Problem: The development of chronic myeloid leukaemia is the result of a reciprocal translocation between chromosome 9 and chromosome 22 due to the emergence of Philadelphia chromosome. The product of this mutation is a hybrid onco-protein Bcr-Abl. According to the results of mass spectrometric analysis, GLG1 protein was identified as a potential candidate for interaction with Bcr-Abl. GLG1 protein occupies a privileged position in the signalling pathways of the Golgi complex, participates in the regulation of adhesion, migration, motility processes in cell. We believe that the Bcr-Abl phosphorylates GLG1 and thus deregulates its activity and disrupts numerous downward signalling pathways, leading to the progression of chronic myeloid leukaemia. Methodology & Theoretical Orientation: K562 cells were selected for the experiment. The studies were performed.. Read More»
  

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