NUT midline carcinoma of the lung


Author(s): Khaoula Alaoui Ismaili*, Samia Arifi, Zineb Benbrahim, Karima Oualla, Hind Elfatmi, Mariam Boubou, Lamiae Amaadour, Meryem Zaryouhi, Yahya Morabiti, Imane Stitou, Mohammed Ismaili and Naoufal Mellas

NUT Midline Carcinoma (NMC) is a highly lethal, genetically defined, and rare undifferentiated cancer that occurs in the midline region of the mediastinum, head or neck.

We report in this study the case of a 35-year-old male who was diagnosed with a locally advanced mediastinal tumour. However, pathology with immunohistochemistry confirmed the diagnosis of poorly differentiated carcinoma and excluded the diagnosis of germ cell tumour (AFP BHCG markers negative). Although aggressively treated, the course was marked by a fast clinical deterioration which led to death within three months of the first diagnosis. The aim of this study is to highlight the rareness of this condition, the pathological and clinic-radiological characteristics, the management of the treatment and the prognosis.

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Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


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