Jolanta Rzymowska

Chair, Department of Biology and Genetics, Medical University, Lublin, Poland

Publications

  • Original Article   
    Bcl-2 expression in breast carcinoma cells in vitro
    Author(s): Jolanta Rzymowska

    Apoptosis is a physiological form of cell death that occurs in all tissues Deregulated expression of some oncogenes causes increased cell division and advances cell growth. The balance between bcl-2 and c-myc and c-jun seems to be an important determinant of cellular sensitivity to the induction of apoptosis. Bcl-2 gene promotes cell survival rather than cell proliferation In the our study bcl-2 has been demonstrated to inhibit apoptosis in breast cancer cells in vitro (T47D). High expression of bcl-2 was noticed to be strongly related to low rates of apoptotic and necrotic cell death. The mean value of the apoptotic index was 7.5% in bcl-2-negative tumours and 0.55% in bcl-2-positive tumours. High proliferation rate was associated with the absence of bcl-2 expression. C-myc and c-jun accumulation were associated with the presence of bcl- 2 expression and .. Read More»

    Abstract PDF

+44 7456035580

Editors List

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

  • Krzysztof Urbanski

    Head of the Oncology Gynecology Clinic, Oncology Center - Instytut im. Maria Sklodowska Curie, Department in Krakow (Krakow, Poland)

  • Andrzej Szawlowski

    Klinika Nowotworow Gornego Odcinka Uklad Digestii, Oncology Center - Institute (Warsaw, Poland)