Thyroid functions consequences following adjuvant chemotherapy for breast cancer after mastectomy
The goal: It is to evaluate the effect of adjuvant chemotherapy on thyroid function in women with diagnosed breast cancer after radical mastectomy and prior to radiotherapy.
Patients and interventions: Forty Egyptian women with age ranging from 18 to 60 years who adminstered 5-flourouracil, epirubicin and cyclophosphamide as adjuvant therapy for breast cancer after mastectomy and prior to radiotherapy. Free T3, Free T4, TSH, anti-thyroglobulin antibody and thyroid peroxidase antibody were evaluated prior and after 6 cycles of treatment with chemotherapy.
Results: There were highly statistically significant difference in TSH p=0.005 being higher after chemotherapy, also in free T4 values P=0.025 being lower after chemotherapy. There was no statistically significant difference in free T3 P=0.051, Concerning both anti-thyroglobulin and anti-peroxidase there was no change in values before and after chemotherapy.
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Prof. Elhadi Miskeen
Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia
Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
Fava Maria Giovanna
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