Thyroid functions consequences following adjuvant chemotherapy for breast cancer after mastectomy


Author(s): Hany Khairy Mansour* and Laila Mahmoud Ali Hendawy

The goal: It is to evaluate the effect of adjuvant chemotherapy on thyroid function in women with diagnosed breast cancer after radical mastectomy and prior to radiotherapy. Patients and interventions: Forty Egyptian women with age ranging from 18 to 60 years who adminstered 5-flourouracil, epirubicin and cyclophosphamide as adjuvant therapy for breast cancer after mastectomy and prior to radiotherapy. Free T3, Free T4, TSH, anti-thyroglobulin antibody and thyroid peroxidase antibody were evaluated prior and after 6 cycles of treatment with chemotherapy. Results: There were highly statistically significant difference in TSH p=0.005 being higher after chemotherapy, also in free T4 values P=0.025 being lower after chemotherapy. There was no statistically significant difference in free T3 P=0.051, Concerning both anti-thyroglobulin and anti-peroxidase there was no change in values before and after chemotherapy Conclusion: Adjuvant chemotherapy in women with breast cancer led to a rise of TSH and lower fT4 levels which although still being in normal, it may grounds for longer follow up to detect overt hypothyroidism later in life.

Share this article

Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

Google Scholar citation report
Citations : 61

Onkologia i Radioterapia received 61 citations as per Google Scholar report

Onkologia i Radioterapia peer review process verified at publons
Indexed In
  • Scimago
  • MIAR
  • Euro Pub
  • Google Scholar
  • Medical Project Poland
  • Cancer Index
  • Gdansk University of Technology, Ministry Points 20