Synthesis, Characterization And Cytotoxic Activity Study Of Mn (II), Co (II), And Metal Complexes With New Schiff Base Against The Hepatocellular Carcinoma (SK-GT-4) Cancer Cell


Author(s): Zaid N. O. Al-Husseini, Jasim M. S. Alshawi

This paper involved the synthesis of a new compound by condensing O- Phenylenediamine (OPD) and 4-Methyl-o-phenylenediamine with pyrrole-2-carboxaldehyde through a condensation reaction. Following that, transition metal complexes of Mn (II) and Co (II) were prepared by reacting the respective metal chlorides with the ligand in a 1:1 molar ratio. To characterize the ligand and its metal complexes, a comprehensive range of spectroscopic and analytical techniques was employed, confirming their tetrahedral geometry. Additionally, the researchers investigated the potential cytotoxic effects of hepatic cells cancer (SK-GT-4) cancer cells treated with the Schiff bases and its metal compounds.

Share this article

Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


Google Scholar citation report
Citations : 208

Onkologia i Radioterapia received 208 citations as per Google Scholar report

Onkologia i Radioterapia peer review process verified at publons
Indexed In
  • Directory of Open Access Journals
  • Scimago
  • MIAR
  • Euro Pub
  • Google Scholar
  • Medical Project Poland
  • Cancer Index
  • Gdansk University of Technology, Ministry Points 20