Synthesis and characterization of new 1, 3, 4-thiadiazole derivatives of naproxen as a potential antineoplastic agent

Abstract

Author(s): Aamer A. Chaab* and Mazin N. Mousa

Cancer is a dangerous issue affecting the validity of each human community, which interferes with a cellular connection and results in critical gene dysfunction. This disorder is efficient in the cell cycle and causes proliferation abnormality. This study was performed in the synthesis of five derivatives of 1, 3, and 4-thiadiazole associated with Schiff bases. The synthesis was initiated by the reaction of Naproxen with thiosemicarbazide in the presence of Phosphorous Oxychloride (POCl3), which undergoes cyclization reaction upon neutralization with sodium bicarbonate aqueous solution forming 1, 3, 4-thiadiazole. Then it was reacted with different aromatic aldehydes converted to Schiff bases. The chemical structure of newly synthesized compounds was emphasized by using 1H-NMR, 13C-NMR, FT-IR, and C, H, N analysis. The activity of all synthesized compounds by Mtt assay to evaluated comparison with standard drug (Naproxen). It was revealed activity upon cellular inhibition on Mtt. The newly synthesized compounds are successfully prepared depending on FT-IR, 1H-NMR, 13C-NMR, and C, H, N analysis data, and they revealed anti-neoplastic activity compared with standard

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