Prognostic value of FGFR3 expression in Urinary bladder cancer

Abstract

Author(s): Awatif Z. Abdiwi, Asst. Professor. Hameed Naeem Mousa, Prof. Dr. Husam Mohammad

The aim of this study is to determine the expression of the FGFR3protein in human bladder cancer, and significant correlations between these parameters and clinico pathologic variables like (grade and stage. the bladder cancer is one of the most common cancers worldwide. the incidence and mortality of this disease increased during last decades alarmingly in Iraq. The current study is designed to detect the role of FGFR3expression in bladder carcinoma as a possible marker for detecting the biological behavior of malignancy and its correlation with grade and non-muscle invasive bladder cancer NMIBC. for both diagnostic and prognostic purposes. The study focuses on a technique of immunohistochemistry for detection FGFR3expression in bladder cancer. The samples are collected randomly in southern Iraq, in AL-Nasiriya city, from AL Hussein teaching hospital. Number of samples is 100 ,70 bladder cancer tissue and 30 controls benign tissue. Results of this study reveal that FGFR3expression is positive in 49 of 70 sample. The study demonstrated FGFR3 expression is increased in low grade bladder cancer represent (96.30%), while in high grade (53.49%), FGFR3expression high in Ta stage (100%) , and in T1(100%) T2(51.28) T3 (50%) expression FGFR3excessive in non-muscle invasive (92.85%), whilst the low expression for FGFR3in the muscle invasive type (54.76%). So FGFR3can be used as a marker for assessment of bladder cancer aggressiveness. This study represents an important step because there are few of studies about this topic in Iraq; we are needing more studies to prove the function of this FGFR3in biological behavior of bladder cancer.

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