From Rubus idaeus to Oncology: A Critical Review of Raspberry Ketone as a Plant-Derived Bioactive Compound in Cancer Prevention, Redox Regulation, and Molecular Therapeutic Pathways

Abstract

Author(s): Ammapalli Sravanthi* and P. Dharani Prasad

Raspberry ketone, a bioactive phenolic compound derived from Rubus idaeus, has gained attention for its potential role in cancer prevention and supportive oncology. Preclinical studies demonstrate that it exerts antioxidant, antiinflammatory, and pro-apoptotic effects, modulating redox balance, cell cycle progression, and inflammatory signaling. In vitro studies show inhibition of proliferation and induction of apoptosis across multiple cancer cell lines, while in vivo models report reduced tumor growth, enhanced antioxidant enzyme activity, and improved survival outcomes. Despite these promising findings, translation into clinical use is limited by low oral bioavailability, rapid metabolism, and lack of standardized dosing. Safety data on long-term high-dose exposure remain insufficient, highlighting the need for rigorous pharmacokinetic and toxicological studies. Future research should focus on novel delivery systems, combination therapies with conventional treatments, and well-designed clinical trials to establish efficacy and safety. Understanding the molecular mechanisms underlying raspberry ketone’s anticancer effects can support its development as a plant-derived adjunct in cancer prevention and integrative oncology.

Share this article