Expression of PD/PD-L1 as a prognostic biomarker in ovarian serous carcinoma carcinoma - A literature review


Author(s): Astrit M. Gashi, Brikene Elshani*, Hajrullah Latifi, Gent Sopa, Jakup Ismajli and Arianit Sherifi

Ovarian cancer has the highest mortality rate of any gynecologic malignancy other. Even after optimal treatment, the prognosis remains poor. To date, no biomarker can predict the individual outcome of a patient with this disease. Two decades of studies have investigated the prognostic value of PD-1/PD-L1 in high-grade serous ovarian carcinoma; many issues remain unclear, controversial, inconsistent, and often contradictory. PD-L1 is an important immunoregulatory factor and, as a receptor for PD-1, plays an important role in inhibiting the immune response to cancer cells, thus negatively regulating T cell functions. The level of expression in PD-L1 is related to the patient's survival rate and prognosis in various types of cancers, including ovarian cancer, particularly serous ovarian carcinoma. The level of expression in PD-L1 increases the potency of tumour immunogenicity, increases the rate of an effective response to immunotherapy treatment, increases the overall survival rate, improves the most favorable prognosis of patients, and is applied in the molecular classification of high-grade serous ovarian carcinoma; therefore a high expression of PD-L1 is considered as an independent and favorable prognostic biomarker in all histological types of ovarian cancers, especially in serous ovarian carcinomas.

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Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


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