Expression of sortilin in pancreatic carcinoma and influence of pancreatic cancer cells by sortilin sirna knockdown


Author(s): Astrit Gashi

Background: Currently, there are few effective therapeutic options for pancreatic cancer patients.Sortilin is a member of vps10p receptor family?reported in many types of cancers.However, the underlying mechanism and prognostic value of sortilin in pancreatic cancer are still unclear. Objective:Understand the expression of sortilin in pancreatic cancer, and analyze its mechanism that affects the occurrence and development of pancreatic cancer. Abbreviations: PC:Pancreatic cancer;ROC:the receiver operating characteristic;SEIN:Sortilin expression in nucleus;NTs:Neurotrophic factor family;min:minute;sec:second;BLR:Binary Logistic Regression ;siRNA:small interference RNA;IHC:Immunohistochemistry;RTPCR:Reverse Transcription Polymerase Chain Reaction.

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Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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