Exploring the significance of zone 1 in human protein interaction networks: Identifying potential therapeutic targets for cancer treatment


Author(s): Hassan Ramzy Alqattan and Emad Fadhal*

Protein-protein interaction networks are important tools for understanding the complex nature of biological processes and diseases, particularly cancer. However, the large size and complexity of these networks make it difficult to identify the most critical nodes that play important roles and act as critical regulators or mediators of biological processes in the networks. Identifying these key nodes within protein-protein interaction networks across different cancer types is crucial for elucidating the underlying molecular mechanisms and identifying potential therapeutic targets. Therefore, this study aims to analyse the significance of zone 1 in the human protein interaction network using the graph theory tool to identify the potential most important nodes across various cancer types.

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Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


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