Enhanced Phototherapeutic Effects of Laser-Irradiated Ag NPs-Decorated TiO? Nanotubes in Colon Cancer Cells

Abstract

Author(s): Maher I. Al-Shemri1, S. Z. Mortazavi1,2*, M. R. Khanlary1, Rana A. Ghaleb3, A. Reyhani1

Silver nanoparticles (Ag NPs) successfully decorated on titanium dioxide (TiO2 ) nanotubes (NTs). The effect of Ag NPs decorated TiO2 NTs on colon cancer cells (SW480 cells) is investigated with/without laser exposure at 532 and 808 nm in different times and various concentrations (15.6, 31.25, 62.5, 125, 250, 500μg/ mL). The aims to determine different doses and effective concentrations of Ag NPs-decorated TiO2 for low-energy laser treatment. Colon cancer (SW480) cells y was conducted for the green laser (=532 nm, power=300 mW) and NIR laser rays (= 808 nm, power=150 mw). The untreated cells (control group) maintain a high level of viability across all concentrations of Ag NPs decorated TiO2 NTs. The results indicate that the treatment with Ag NPs-decorated TiO2 NTs and green laser significantly reduced the cancer cell viability in a dose-dependent manner. This study demonstrates the potential of Ag NPs-decorated TiO2 NTs as a novel nanomaterial for photothermal therapy of colon cancer. This approach has several advantages over conventional therapies, including minimal invasiveness, and reduced side effects.

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Awards Nomination oncologyradiotherapy scopus oncologyradiotherapy pubmed

Editors List

  • RAOUi Yasser

    Senior Medical Physicist

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh

     

     

     

  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis

     

  • Fava Maria Giovanna

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