Dosimetric characterization of Flexisource HDR 192Ir brachytherapy source using GATE/GEANT4 Monte Carlo code

Abstract

Author(s): A. Oustous, Z. Airouss, Y. El Attaoui, Y.Raoui, M. Khalis, R. Sebihi

Aim: The aim of this study is to validate the dosimetric parameters of High Dose Rate 192Ir Flexi-source (mHDR v1 model) using GATE (version 9.1) Geant4-based Monte Carlo code, which is widely used in clinical applications for brachytherapy. This validation serves as a preliminary step toward investigating the issues related to tissue heterogeneities in brachytherapy dosimetry.

Methods: In this study, the geometry of the 192Ir Flexi-source mHDR-v1 was simulated within a water sphere using GATE Monte Carlo code. The dosimetric parameters, including air kerma strength Sk, dose rate constant λ, radial dose function g(r), and anisotropy function F (r, θ), were computed in accordance with the TG- 43U1 and ESTRO guidelines, and the results were compared with available literature and clinical data for validation.

Results: The dose rate constant obtained was 1.078 cGy h−1 U−1 ± 0.012 cGy h−1 U−1, showing a relative difference of 2.79% compared to the reference value. The radial dose function, starting from 0.25 cm to 15 cm, showed excellent agreement with a maximum of 3.43% at 15 cm. For the anisotropy function F (r, θ), the agreements were within 4.45% for 5<θ<175, and within 13.29% for all θ values.

Conclusion: Results from this study demonstrate that the validation of the Flexi-source HDR 192Ir source is achievable using the GATE based Monte Carlo simulation. Consequently, the GATE code can be employed to explore challenges associated with tissue heterogeneities in brachytherapy dosimetry for 192Ir Flexi-source.

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Awards Nomination

Editors List

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh

     

     

     

  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis

     

  • Fava Maria Giovanna

     

  • Manuprasad Avaronnan

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