Research Article - Onkologia i Radioterapia ( 2022) Volume 16, Issue 10

Incidence of perioperative cardiac complications in patients with heart disease undergoing major oncosurgeries: A retrospective study

Sonali Opneja1, Roopesh Sureshan1*, Satheeshan Balasubramanian2, Jashma Nizam1, Joona Prabhakaran1, Namratha Divakaran4, Rahul Raveendran3 and Riyas M4
 
1Assistant Professor, Department of Anaesthesia, Malabar Cancer Centre, Thalassery, Kerala, India, India
2Director, Malabar Cancer Centre, Kerala, India
3Senior Resident, Department of Onco-anaesthesiology, Malabar Cancer Centre, Kerala, India
4Lecturer, Department of Biostatistics, Malabar Cancer Centre, Kerala, India
 
*Corresponding Author:
Roopesh Sureshan, Assistant Professor, Department of Anaesthesia, Malabar Cancer Centre, Thalassery, Kerala PO-670 103, India, Email: roopesh14488@gmail.com

Received: 22-Sep-2022, Manuscript No. OAR-22-75608; Accepted: 12-Oct-2022, Pre QC No. OAR-22-75608 (PQ); Editor assigned: 24-Sep-2022, Pre QC No. OAR-22-75608 (PQ); Reviewed: 05-Oct-2022, QC No. OAR-22-75608 (Q); Revised: 10-Oct-2022, Manuscript No. OAR-22-75608 (R); Published: 14-Oct-2022

Abstract

Background: Cardiac complications are the most important causes of morbidity and mortality in the first 30 days after non cardiac surgery which result in prolonged length of stay, increased health care costs and poorer prognosis. Patients with coronary artery disease undergoing non-cardiac surgery are at an increased risk for peri-operative complications such as Myocardial Infarction(MI), cardiac failure, arrhythmias, cardiac arrest and increased morbidity and mortality.

Aim: To know the incidence of perioperative cardiac complications in patients with heart disease undergoing major oncosurgeries.

Settings and design: A retrospective analytic study was done in a tertiary care cancer centre in 70 heart disease patients who underwent oncosurgeries to know the incidence of perioperative cardiac complications within 7 days after surgery. Heart disease which were included in this study were congenital heart disease, ischemic heart disease, moderate and severe mitral stenosis, aortic stenosis, mitral regurgitation, aortic regurgitation, hypertrophic obstructive cardiomyopathy. Perioperative cardiac complications were noted in these patients intraoperatively and 7 days postoperatively.

Results: For the multivariate analysis, the value of alpha was adjusted and p-values at or below 0.2 were considered to be significant. In this study, history of previous surgery and moderate and high risk as diagnosed by cardiologist were found to significantly affect the incidence of intra/post-op complication in cardiac patients undergoing oncosurgeries.

Conclusion: Patients having any heart disease and having history of previous surgery or moderate and high risk diagnosed by cardiologist have more cardiac complications.

Keywords

heart disease, complications, oncosurgeries

Introduction

Cardiac complications are the most important causes of morbidity and mortality in the first 30 days after non-cardiac surgery which result in prolonged length of stay, increased health care costs and poorer prognosis and associate with perioperative factors, including advanced age, Coronary Artery Disease (CAD), renal insufficiency, diabetes, congestive Heart Failure (HF), types of surgery and other conditions [1-4].

Patients with coronary artery disease undergoing non-cardiac surgery are at an increased risk for peri-operative complications such as myocardial ischemia, MI, cardiac failure, arrhythmias, cardiac arrest and increased morbidity and mortality. These complications are much higher in patients with recent MI or unstable angina who require urgent or emergency cardiac surgery [1,5].

Material and Methods

This retrospective study was conducted after obtaining clearance from Institutional review board(1616/IRB-SRC/13/ MCC/08-01-2022/1). It was also registered in Clinical registry trial(CTRI/2022/01/039773). The primary objective of this retrospective study was to estimate the incidence and nature of cardiac complications in patients with heart disease intraoperatively and within 7 days postoperatively undergoing major oncosurgeries. Secondary objective was to assess the risk factors associated with perioperative cardiac complications and to know the thirty-day mortality and 90 days’ mortality in patients with known cardiac illness undergoing major resection surgeries

This study was conducted in the department of oncoanaesthesiology, Malabar Cancer Centre. The data of patients who had any heart disease diagnosed by cardiologist and had undergone major oncosurgeries from 1st January 2021 to 31st December 2021 was retrieved from Medical Records Department.

Inclusion criteria was age 25 years-85 years, ASA I and ASA II patients and those undergoing major oncosurgeries. Patients undergoing emergency surgery, American Society of Anesthesiologists (ASA) classification IV, V or VI and those who underwent two operations or more during the same hospitalization were excluded from this study

Patients having any heart disease were studied for intraoperative cardiac complications and postoperative complications within 7 days of surgery.

CAD was diagnosed if any of the following conditions were met: CAD confirmed by coronary angiography, history of Myocardial Infarction (MI), history of coronary revascularization, positive myocardial perfusion scintigraphy, positive exercise stress test, or typical symptoms of angina pectoris with simultaneous signs of myocardial ischemia on the electrocardiograph

Heart disease which were included in this study: Congenital heart disease, Ischemic heart disease, moderate and severe mitral stenosis, moderate and severe aortic stenosis, moderate and severe mitral regurgitation, moderate and severe aortic regurgitation, hypertrophic obstructive cardiomyopathy.

Perioperative Cardiac Complications (PCCs) were defined as: ACS included ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS). NSTE-ACS was further subdivided into non-ST-elevation MI and unstable angina according to the cardiac biomarkers.

Diagnosis of MI required a cTnl rise above the 99th percentile, accompanied by chest pain, ST-segment changes or new-onset left bundle branch block, ventricular wall motion abnormalities, or angiography confirmation. HF was diagnosed mainly by active clinical symptoms of dyspnea, orthopnea, peripheral edema, jugular venous distention, rales, third heart sound, or chest X-ray with pulmonary vascular redistribution or pulmonary oedema. New-onset severe arrhythmia was defined as ECG changes needing to be treated with drug or electrical conversion, including malignant ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation), atrial flutter or Atrial Fibrillation (AF), atrioventricular block (second-degree type II or third-degree), or frequent ventricular premature contractions.

Cardiac arrest was defined as the loss of circulation prompting resuscitation requiring chest compressions, defibrillation, or both.or physical examination findings. Patients records were collected and analyzed for intraoperative and postoperative complications.

Statistics

Categorical variables were presented as numbers (%), and continuous variables was presented as the mean ± Standard Deviation (SD) or median and Inter-Quartile Range (IQR), depending on the distribution. A chi-square analysis was used between groups with and without PCCs to select possible risk factors of PCCs. SPSS software (IBM corporation) version 21 was used.

Results

70 patients were diagnosed with heart disease in 2021. Out of these 70 patients,62 patients underwent major oncosurgeries in Malabar cancer Centre. Table 1 shows the demographic data of these 62 patients.

Tab. 1. Table representing various patient parameters, n=62

Characteristic N=621
Age Median, (IQR) 65.00, (58.00, 70.00)
Range 38.00, 77.00
Mean ± SD 63.24 ± 9.35
Sex F 29 (46.77%)
M 33 (53.23%)
IHD 52 (83.87%)
Hypertension 37 (59.68%)
Diabetes 27 (43.55%)
Stroke 2 (3.23%)
Weight (kg) Median, (IQR) 58.00, (52.25, 65.00)
Range 35.00, 98.00
Mean ± SD 59.44 ± 10.93
ASA Status I 1 (1.61%)
II 36 (58.06%)
III 25 (40.32%)
  Characteristic N=62
BUN Median, (IQR) 22.00, (16.00, 28.75)
Range 8.00, 71.00
Mean ± SD 23.84 ± 10.74
Creatinine Median, (IQR) 0.90, (0.80, 1.00)
Range 0.40, 8.00
Mean ± SD 1.02 ± 0.95
Serum Sodium Median, (IQR) 136.00, (133.00, 139.00)
Range 126.00, 144.00
Mean ± SD 135.94 ± 3.87
Serum Potassium Median, (IQR) 4.40, (4.00, 4.60)
Range 3.40, 5.20
Mean ± SD 4.32 ± 0.45
Random Blood Sugar Median, (IQR) 120.50, (97.25, 148.75)
Range 66.00, 357.00
Mean ± SD 136.15 ± 55.31
INR Median, (IQR) 1.00, (1.00, 1.00)
Range 1.00, 1.27
Mean ± SD 1.01 ± 0.04
TSH Median, (IQR) 1.76, (0.97, 2.53)
Range 0.38, 9.96
Mean ± SD 2.13 ± 1.76
Characteristic History of Surgery 19 (30.65%)
Incidence of complications 17 (27.42%)
Incidence of intra-op complications 6 (9.68%)
Incidence of Post-op Complications 11 (17.74%)

17 patients developed complications, out of which 6 patients developed intraoperative complications and 11 patients developed postoperative complications.

Table 2 shows the intraoperative complications in these 6 patients

Intraoperative complications No. of patients
Hypotension 1
Bradycardia 2
Hypertension 3
Total 6

Table 3 shows the postoperative complications in 17 patients.

Tab. 3. Postoperative complications.

Postoperative complications Number of patients
Bleeding 2
ECG changes, Trop I normal 1
Saturation fall 1
Hypotension 3
ECG changes, Trop I elevated 1
Hypertension 2
Bradycardia 1
Total 11

Tab. 4. Shows the comparison of patient parameters as per incidence of complications

Characteristic No, N=451 Yes, N=171 p-value2
Age Median (IQR) 65.00, (58.00, 70.00) 65.00, (58.00, 69.00) 0.6
Range 43.00, 77.00 38.00, 73.00
Mean ± SD 63.62 ± 9.41 62.24 ± 9.42
Sex F 21 (46.67%) 8 (47.06%) >0.9
M 24 (53.33%) 9 (52.94%)
IHD 38 (84.44%) 14 (82.35%) >0.9
Hypertension 25 (55.56%) 12 (70.59%) 0.3
Diabetes 18 (40.00%) 9 (52.94%) 0.4
Stroke 1 (2.22%) 1 (5.88%) 0.5
Weight (kg) Median, (IQR) 60.00, (53.00, 67.00) 57.00, (49.00, 63.00) 0.3
Range 39.00, 80.00 35.00, 98.00
Mean ± SD 60.16 ± 9.74 57.53 ± 13.75
ASA Status I 1 (2.22%) 0 (0.00%) 0.6
II 24 (53.33%) 12 (70.59%)
III 20 (44.44%) 5 (29.41%)
History of Surgery 17 (37.78%) 2 (11.76%) 0.047
Haemoglobin Median, (IQR) 12.10, (11.10, 13.80) 11.50, (9.80, 13.60) 0.4
Range 8.10, 17.60 8.20, 15.80
Mean ± SD 12.31 ± 1.89 11.74 ± 2.17
Total Leucocyte Count Median, (IQR) 8,500.00, (6,700.00, 10,100.00) 8,100.00, (6,300.00, 10,500.00) 0.7
Range 4,000.00, 15,100.00 4,700.00, 25,200.00
Mean ± SD 8,646.67 ± 2,561.04 9,088.24 ± 4,659.38
Platelet Count Median, (IQR) 268,000.00, (237,000.00, 339,000.00) 243,000.00, (206,000.00, 274,000.00)

0.072

Range 128,000.00, 501,000.00 178,000.00, 343,000.00

 

Mean ± SD 281,888.89 ± 87,464.60 244,588.24 ± 51,592.22

 

BUN Median, (IQR) 23.00, (19.00, 28.00) 21.00, (15.00, 29.00) 0.5
Range 8.00, 71.00 13.00, 41.00
Mean ± SD 24.44 ± 11.51 22.24 ± 8.45
Creatinine Median, (IQR) 0.90, (0.70, 1.00) 0.90, (0.80, 1.00) 0.7
Range 0.50, 1.90 0.40, 8.00
Mean ± SD 0.94 ± 0.31 1.25 ± 1.75
Serum Sodium Median, (IQR) 136.00, (134.00, 138.00) 136.00, (133.00, 139.00) 0.6
Range 126.00, 144.00 131.00, 144.00
Mean ± SD 135.71 ± 3.82 136.53 ± 4.06
Serum Potassium Median, (IQR) 4.40, (4.00, 4.60) 4.50, (4.20, 4.70) 0.12
Range 3.40, 5.20 4.00, 5.00
Mean ± SD 4.26 ± 0.48 4.48 ± 0.31
Random Blood Sugar Median, (IQR) 119.00, (98.00, 149.00) 121.00, (97.00, 148.00) 0.8
Range 70.00, 357.00 66.00, 194.00
Mean ± SD 139.60 ± 60.85 127.00 ± 36.89
INR Median, (IQR) 1.00, (1.00, 1.00) 1.00, (1.00, 1.02) 0.4
Range 1.00, 1.27 1.00, 1.13
Mean ± SD 1.01 ± 0.04 1.01 ± 0.03
TSH Median, (IQR) 1.72, (0.97, 2.59) 2.02, (1.01, 2.30) 0.9
Range 0.38, 9.96 0.50, 5.17
Mean ± SD 2.17 ± 1.89 2.02 ± 1.40

From the various factors, history of previous surgery was found to be statistically significant. This means that those patients who had previous surgery were at more risk for developing cardiac complications.

Tab. 5.The comparison of patient parameters as per incidence of intra-op complications.

Characteristic No. N= 561 Yes. N=61 p-value2
Age Median (IQR) 65.00, (57.75, 70.00) 68.00, (60.25, 69.75) 0.7
Range 38.00, 77.00 52.00, 72.00
Mean ± SD 63.09 ± 9.55 64.67 ± 7.89
Sex F 26 (46.43%) 3 (50.00%) >0.9
M 30 (53.57%) 3 (50.00%)
IHD 47 (83.93%) 5 (83.33%) >0.9
Hypertension 32 (57.14%) 5 (83.33%) 0.4
Diabetes 25 (44.64%) 2 (33.33%) 0.7
Stroke 2 (3.57%) 0 (0.00%) >0.9
Weight (kg) Median, (IQR) 59.00, (52.75, 65.50) 56.00, (49.00, 63.00) 0.4
Range 39.00, 98.00 35.00, 66.00
Mean ± SD 60.00 ± 10.80 54.17 ± 11.70
ASA Status I 1 (1.79%) 0 (0.00%) 0.4
II 31 (55.36%) 5 (83.33%)
III 24 (42.86%) 1 (16.67%)
Hemoglobin Median, (IQR) 11.95, (10.90, 13.72) 12.35, (11.55, 13.38) 0.8
Range 8.10, 17.60 8.60, 14.40
Mean ± SD 12.16 ± 1.98 12.12 ± 2.03
Total Leucocyte Count Median, (IQR) 8,500.00, (6,650.00, 10,425.00) 7,400.00, (6,450.00, 8,050.00) 0.3
Range 4,000.00, 25,200.00 6,300.00, 9,300.00
Mean ± SD 8,907.14 ± 3,357.81 7,466.67 ± 1,182.65
Platelet Count Median, (IQR) 265,000.00, (215,500.00, 303,750.00) 270,000.00, (237,750.00, 326,250.00) >0.9
Range 128,000.00, 501,000.00 178,000.00, 343,000.00
Mean ± SD 271,607.14 ± 82,640.66 272,166.67 ± 64,396.95
BUN Median, (IQR) 22.00, (16.00, 28.50) 22.00, (16.75, 27.25) 0.8
Range 8.00, 71.00 14.00, 30.00
Mean ± SD 24.04 ± 11.11 22.00 ± 6.72
Creatinine Median, (IQR) 0.90, (0.78, 1.00) 0.90, (0.83, 0.90) 0.7
Range 0.40, 8.00 0.60, 1.00
Mean ± SD 1.04 ± 0.99 0.85 ± 0.14
Serum Sodium Median, (IQR) 136.00, (133.75, 139.00) 136.00, (132.25, 142.00) 0.7
Range 126.00, 144.00 131.00, 144.00
Mean ± SD 135.82 ± 3.67 137.00 ± 5.76
Serum Potassium Median, (IQR) 4.45, (4.00, 4.60) 4.30, (4.20, 4.55) >0.9
Range 3.40, 5.20 4.00, 4.80
Mean ± SD 4.32 ± 0.46 4.37 ± 0.29
Random Blood Sugar Median, (IQR) 120.00, (97.00, 153.25) 125.50, (105.75, 140.00) 0.9
Range 66.00, 357.00 89.00, 148.00
Mean ± SD 137.66 ± 57.61 122.00 ± 23.38
INR Median, (IQR) 1.00, (1.00, 1.00) 1.00, (1.00, 1.02) 0.5
Range 1.00, 1.27 1.00, 1.13
Mean ± SD 1.01 ± 0.04 1.03 ± 0.05
TSH Median, (IQR) 1.76, (0.96, 2.52) 1.98, (1.17, 4.44) 0.5
Range 0.38, 9.96 0.77, 5.17
Mean ± SD 2.07 ± 1.74 2.68 ± 2.00
History of Surgery 19 (33.93%) 0 (0.00%) 0.2
1n (%)
2Wilcoxon rank sum test; Fisher's exact test
Serum Potassium Median, (IQR) 4.45, (4.00, 4.60) 4.30, (4.20, 4.55) >0.9
Range 3.40, 5.20 4.00, 4.80
Mean ± SD 4.32 ± 0.46 4.37 ± 0.29
Random Blood Sugar Median, (IQR) 120.00, (97.00, 153.25) 125.50, (105.75, 140.00) 0.9
Range 66.00, 357.00 89.00, 148.00
Mean ± SD 137.66 ± 57.61 122.00 ± 23.38
INR Median, (IQR) 1.00, (1.00, 1.00) 1.00, (1.00, 1.02) 0.5
Range 1.00, 1.27 1.00, 1.13
Mean ± SD 1.01 ± 0.04 1.03 ± 0.05
TSH Median, (IQR) 1.76, (0.96, 2.52) 1.98, (1.17, 4.44) 0.5
Range 0.38, 9.96 0.77, 5.17
Mean ± SD 2.07 ± 1.74 2.68 ± 2.00
History of Surgery 19 (33.93%) 0 (0.00%) 0.2
1n (%)
2Wilcoxon rank sum test; Fisher's exact test

Tab. 6. The comparison of patient parameters as per incidence of post-op complications.

Characteristic No, N=511 Yes, N=111 p-value2
Age Median, (IQR) 65.00, (58.00, 70.00) 65.00, (56.00, 68.00) 0.4
Range 43.00, 77.00 38.00, 73.00
Mean ± SD 63.75 ± 9.18 60.91 ± 10.26
Sex F 24 (47.06%) 5 (45.45%) >0.9
M 27 (52.94%) 6 (54.55%)
IHD 43 (84.31%) 9 (81.82%) >0.9
Hypertension 30 (58.82%) 7 (63.64%) >0.9
Diabetes 20 (39.22%) 7 (63.64%) 0.2
Stroke 1 (1.96%) 1 (9.09%) 0.3
Weight (kg) Median, (IQR) 60.00, (52.50, 65.50) 57.00, (52.00, 61.50) 0.6
Range 35.00, 80.00 41.00, 98.00
Mean ± SD 59.45 ± 10.05 59.36 ± 14.95
ASA Status I 1 (1.96%) 0 (0.00%) >0.9
II 29 (56.86%) 7 (63.64%)
III 21 (41.18%) 4 (36.36%)
Hemoglobin Median, (IQR) 12.10, (11.15, 13.70) 11.20, (9.75, 12.85) 0.2
Range 8.10, 17.60 8.20, 15.80
Mean ± SD 12.29 ± 1.89 11.53 ± 2.30
Total Leucocyte Count Median, (IQR) 8,100.00, (6,700.00, 9,550.00) 8,900.00, (6,150.00, 10,950.00) 0.6
Range 4,000.00, 15,100.00 4,700.00, 25,200.00
Mean ± SD 8,507.84 ± 2,461.53 9,972.73 ± 5,621.23
Platelet Count Median, (IQR) 268,000.00, (236,500.00, 338,000.00) 236,000.00, (198,000.00, 263,000.00) 0.035
Range 128,000.00, 501,000.00 179,000.00, 281,000.00
Mean ± SD 280,745.10 ± 84,597.60 229,545.45 ± 38,471.71
BUN Median, (IQR) 22.00, (17.50, 28.50) 19.00, (15.00, 29.00) 0.5
Range 8.00, 71.00 13.00, 41.00
Mean ± SD 24.16 ± 11.04 22.36 ± 9.57
Creatinine Median, (IQR) 0.90, (0.75, 1.00) 0.90, (0.80, 1.00) >0.9
Range 0.50, 1.90 0.40, 8.00
Mean ± SD 0.93 ± 0.30 1.46 ± 2.18
Serum Sodium Median, (IQR) 136.00, (133.00, 139.00) 136.00, (134.00, 139.00) 0.7
Range 126.00, 144.00 131.00, 140.00
Mean ± SD 135.86 ± 4.04 136.27 ± 3.10
Serum Potassium Median, (IQR) 4.40, (4.00, 4.60) 4.50, (4.35, 4.75) 0.082
Range 3.40, 5.20 4.00, 5.00
Mean ± SD 4.27 ± 0.46 4.55 ± 0.32
Random Blood Sugar Median, (IQR) 120.00, (98.50, 147.50) 121.00, (94.50, 168.00) >0.9
Range 70.00, 357.00 66.00, 194.00
Mean ± SD 137.53 ± 57.84 129.73 ± 43.37
INR Median, (IQR) 1.00, (1.00, 1.00) 1.00, (1.00, 1.01) 0.7
Range 1.00, 1.27 1.00, 1.04
Mean ± SD 1.01 ± 0.04 1.01 ± 0.01
TSH Median, (IQR) 1.72, (0.97, 2.66) 2.02, (0.92, 2.17) 0.5
Range 0.38, 9.96 0.50, 3.09
Mean ± SD 2.23 ± 1.89 1.65 ± 0.84
History of Surgery 17 (33.33%) 2 (18.18%) 0.5
1n (%)
2Wilcoxon rank sum test; Pearson's Chi-squared test; Fisher's exact test

Tab. 7. Shows the univariate regression analysis of various factors

Characteristic N OR1 95% CI1 p-value

 

Age 62 1 0.93, 1.05 0.6
Sex F 62  
M 62 1 0.32, 3.06 >0.9
IHD No 62  
Yes 62 0.9 0.21, 4.41 0.8
History of Surgery No 62  
Yes 62 0.2 0.03, 0.91 0.062
LV changes Absent 62  
Present 62 1 0.30, 2.96 >0.9
Stenosis Absent 62  
Present 62 0   >0.9
ECG changes Absent 62  
Present 62 0.7 0.23, 2.19 0.6
Regurgitation Absent 62  
Present 62 0   >0.9
1OR=Odds Ratio, CI=Confidence Interval 62      

Table 8 shows the multivariate regression analysis of various factors.

Characteristic N OR1 95% CI1 p-value

 

Age 62 1 0.93, 1.05 0.6
Sex F 62  
M 62 1 0.32, 3.06 >0.9
IHD No 62  
Yes 62 0.9 0.21, 4.41 0.8
History of Surgery No 62  
Yes 62 0.2 0.03, 0.91 0.062
LV changes Absent 62  
Present 62 1 0.30, 2.96 >0.9
Stenosis Absent 62  
Present 62 0   >0.9
ECG changes Absent 62  
Present 62 0.7 0.23, 2.19 0.6
Regurgitation Absent 62  
Present 62 0   >0.9
1OR=Odds Ratio, CI=Confidence Interval 62      

For the multivariate analysis, the value of alpha was adjusted and p-values at or below 0.2 were considered to be significant.

In our analysis, history of previous surgery and moderate risk were found to significantly affect the incidence of intra/post-op complication in cardiac patients undergoing oncosurgeries.

The risk of complications in patients who have undergone previous surgery was 24% more than the patients who have not undergone any previous surgery.

Similarly, patients with moderate risk (as assessed by cardiologist) were 4.64 times more likely to develop complications as compared to patients with mild risk. (CI: 0.61, 46.4; p=0.2). Patients with high risk diagnosed by cardiologist were also 1.90 times more likely to develop complications (CI:0.42,9.16; p=0.12).

Discussions

Goldman et al. reported that 500,000-900,000 Myocardial Infarctions (MIs) occur annually worldwide with subsequent mortality of 10%-25%. The number of people with coronary artery disease with or without intervention coming for noncardiac procedures has also increased [6,7].

Large, prospective cohort studies have shown that several chronic cardiac conditions such as coronary artery disease provide a substrate for cardiac complications after surgery [8-11].

Examples of recent preoperative conditions that are independently associated with perioperative cardiac complications are high-risk coronary artery disease (i.e., myocardial infarction or Canadian Cardiovascular Society class (CCSC) III or IV angina within 6 months before surgery), stroke within 3 months before surgery, and coronary-artery stenting within 6 months before surgery [8,12-17].

The incidence of perioperative cardiac complications in our study was 27.41%. Our study revealed history of previous surgery and moderate and high risk as diagnosed by cardiologist as independent risk factors for perioperative cardiac complications.

Table 9 shows the various surgeries studied in our study.

Type of surgery No. of cases
Endometrium and ovary 10
Head and neck 25
Breast 14
Bladder and RCC 3
Colon and Rectum 9
Pheochromocytoma 1
Stomach 8
Total 70

In this study we did not get any correlation between advancing age and incidence of perioperative cardiac complications but previous studies have shown advancing age as independent risk factor for postoperative complications. In a prospective large-scale study, CAD history and age ≥ 75 were both independent predictors of MI in non-cardiac surgery, with 10.3% and 23.5% population attribute risk, respectively [18].

We also found that moderate and high risk as diagnosed by cardiologist was also associated with increased incidence of intraoperative and postoperative cardiac complications.

Several related chronic conditions like cerebrovascular disease, diabetes mellitus, and renal dysfunction and other risk factors in the general population were not independent predictors of PCCs in this study [19,20].

The main limitation of our study is the relatively small number of patients. As a retrospective study, some preoperative information was unavailable including cTnl levels, and we could not comment on the role of preoperative medical management in modifying the risk of PCCs [21].

Postoperative troponin was tested only if clinical or ECG evidence of PCCs, which might lead to a missed diagnosis of silent MI. Moreover, asymptomatic silent troponin level elevation alone is strongly associated with mortality [22].

More prospective studies should be designed to evaluate the risk factors and prophylactic cardiac interventions, and make comprehensive predictive stratification models that allow for better preoperative optimization as to minimize PCCs

Conclusion

The incidence of perioperative cardiac complications is high in patients having history of heart disease. This risk is further increased in patients who have history of previous surgery and those diagnosed as moderate and high risk for surgery by cardiologist. So, special precautions should be taken in these patients to avoid complications both intraoperatively and postoperatively

Financial Support and Sponsorship

Nil

Conflicts of Interest

There are no conflicts of interest

References

Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh

     

     

     

  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis

     

  • Fava Maria Giovanna

     

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