Research Article - Onkologia i Radioterapia ( 2022) Volume 0, Issue 0
Development and validation of a nomogram for predicting the overall survival of patients with pancreatic ductal adenocarcinoma of the head of the pancreas
Zhilong Liu, Haohui Yu, Mingrong Cao, Jiexing Li and Ke Cai*Ke Cai, Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou,Postcode: 510630, China, Email: caike0811@sina.com
Received: 09-Nov-2022, Manuscript No. OAR-22-79432; , Pre QC No. OAR-22-79432(PQ); Editor assigned: 11-Nov-2022, Pre QC No. OAR-22-79432(PQ); Reviewed: 25-Nov-2022, QC No. OAR-22-79432; Revised: 02-Dec-2022, Manuscript No. OAR-22-79432; Published: 09-Dec-2022, DOI: 10.4172/1896-8961.16.1.005
Abstract
Background: The purpose of this study is to develop and validate a nomogram to predict the Overall Survival (OS) of patients with Pancreatic Ductal Adenocarcinoma of the Head of the Pancreas (PDAC-HP).
Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, we collected patients with PDAC-HP in the United States between 2004 and 2015. Patients were randomly divided into training set and validating set at a ratio of 7:3. The training set is used to develop a nomogram for predicting OS. These indicators such as the C index, the area under curve of the receiver operating characteristic, and calibration plots were used to evaluate the prediction accuracy of the nomogram.
Results: A total of 33,893 patients with PDAC-HP over 20 years old were diagnosed between 2004 and 2015. Using multivariable Cox regression analysis, we identified eight risk factors that were associated with OS, such as age at diagnosis, sex, marital status at diagnosis, race, AJCC staging, surgery, radiotherapy and chemotherapy. A nomogram was constructed based on these variables. Compared with the AJCC staging system, the nomogram has a better C index and AUC in the training set and validatiing set. The calibration plots indicated that the nomogram was able to accurately predict the OS of patients with PDAC-HP at 1, 3, and 5 years.
Conclusions: We developed and validated a nomogram, and predicted the OS of patients with PDAC-HP at 1, 3, and 5 years. Compared with the AJCC staging system, the nomogram we constructed has better performance.
Keywords
Nomogram, Pancreatic Ductal Adenocarcinoma; pancreas, malignant tumor
Introduction
Pancreatic cancer is a highly malignant tumor of the digestive tract with a five-year survival rate of approximately 8%. It is reported that there were approximately 460,000 new patients with pancreatic cancer globally in 2018, and their incidence is second only to colorectal cancer and rectal cancer in the digestive system, and about 430,000 patients died of the disease [1,2]. There were approximately 55,000 new patients with pancreatic cancer and 44,000 deaths in the United States in 2018 [1]. It is the tenth most common new tumor and the fourth most common cause of death in the United States [3]. Pancreatic Ductal Adenocarcinoma (PDAC) is the main pathological type of pancreatic cancer, accounting for about 90%, and its degree of malignancy is much higher than other types [4,5].
The pancreas and its accessory tissues are rich in blood vessels and lymph, and pancreatic cancer is prone to metastasis. Therefore, most patients are diagnosed as advanced pancreatic cancer at the first visit, and their prognosis is poor [5,6]. For PDAC patients, surgery is the first choice of treatment, followed by radiotherapy and chemotherapy [7]. Due to the low detection rate of early PDAC patients, most patients have already developed tumor metastasis after the diagnosis of the disease [5,8]. It was found that although surgery can significantly prolong the survival time of PDAC patients, the 5-year survival rate of patients after surgery is only about 20%, due to the high recurrence rate of patients after surgery [9-11]. At present, the tumor staging and prognosis of PDAC patients are mainly based on the AJCC staging system [12]. However, the AJCC staging system does not take into account the influence of age, gender, race, surgery and other factors on tumor prognosis [13,14]. Therefore, constructing a prognostic prediction model with high accuracy and specificity is still of great significance for improving the prognosis of PDAC patients and guiding the treatment of patients.
A nomogram is a predictive model that can combine multiple risk factors [14]. In recent years, the nomogram has been widely used to predict the Overall S14urvival (OS) of different types of cancer patients [15-17]. At present, there are few studies using the nomogram to study the OS of patients with Pancreatic Ductal Adenocarcinoma of the Head of the Pancreas (PDAC-HP). Therefore, the purpose of this study is to explore the potential risk factors that affect the OS of patients with PDAC-HP and construct a nomogram model to predict the OS of 5the patients.
Materials and Methods
Data source
In this study, the data of patients with PDAC-HP in the United States from 2004 to 2015 were derived from the Surveillance, Epidemiology and End Result (SEER) program of the National Cancer Institute. The SEER database collected a variety of cancer data for about 30% of the population in the United States, includSUMMARY ing demographics, tumor characteristics, and survival data [18]. It provides relevant data to all researchers free of charge. We obtained the license to use the SEER database by signing the SEER Research Data Agreement.
Study population and inclusion criteria
Using SEER*Stat (version 8.3.8) software, we identified patients with PDAC-HP from the SEER 18 database based on the code in the International Taxonomy of Tumors (third edition). The main site code of PDAC-HP is C25.0, and the histology code is 8140. The criteria for patient inclusion were 1) Patients with PDAC-HP diagnosed between 2004 and 2015; 2) The age at diagnosis was over 20 years old. The exclusion criteria included: 1) Age under 20 at diagnosis or unknown age; 2) No follow-up date; 3) Unknown race, 4) Unknown AJCC staging. Finally, we collected 33,893 adult patients with PDAC-HP from the SEER database, who were randomly divided into a training set (70%) and a validating set (30%). The screening process of patients with PDAC-HP is shown in Figure 1 in the Supplement. The data collected by all patients included sex, marital status at diagnosis, age at diagnosis, race, region, AJCC staging, surgery, radiotherapy, chemotherapy, and survival time, etc.
Figure 1: The flow diagram of PDAC-HP selection.
Statistical analysis
We screened out independent risk factors that affect the OS of patients with PDAC-HP, using stepwise COX proportional hazards regression analysis. The Akaike Information Criteria (AIC) was used to screen out the final predictor variables and build a nomogram model. The discrimination of the nomogram was evaluated by Harrell's C index (C statistic), and a bootstrap resampling with 1000 iterations was applied to verify the accuracy of the nomogram. The constructed nomogram model is internally compared with the C index of the AJCC staging system (sixth edition). The Area Under Curve (AUC) of the Receiver Operating Characteristic (ROC) was used to evaluate the accuracy of the nomogram in 1, 3- and 5-year survival predictions, and the calibration plots was used to evaluate the performance of the nomogram. Using the Net Reclassification Improvement (NRI) and the Integrated Discrimination Improvement (IDI), we evaluated the accuracy of the nomogram which was compared with that of the AJCC staging system. Finally, the Decision-Curve Analysis (DCA) was used to evaluate the clinical validity of the nomogram. All statistical analyses were performed using R software (version 3.6.3) (http://www.r project.org/). All tests are two-sided tests and P<0.05 is considered statistically significant.
Results
Patient basic characteristics
Table 1 shows the basic characteristics of the patients with PDAC-HP. In this study, we collected 33,893 patients with PDAC-HP over 20 years old were diagnosed between 2004 and 2015. These patients were randomly divided into training set and validating set, including 23,725 patients in the training set and 10,138 patients in the validating set. In the training set, the average age of the patients was 68.4 ± 11.6 years, and the median OS was 11.2 months. In the validating set, the average age of the patients was 68.8 ± 11.7 years, and the median OS was 11.2 months.
Predictors of survival and survival curve
Variables | Overall N (%) | Training set N (%) | Validating set N (%) | p |
---|---|---|---|---|
Patients | 33893 | 23725 (70.0%) | 10168 (30.0%) | |
Age at diagnosis | ||||
Mean ± SD (year) | 68.7 ± 11.7 | 68.8 ± 11.7 | 68.4 ± 11.6 | 0.017 |
Sex | ||||
Female | 16797 (49.6%) | 11821 (49.8%) | 4976 (48.9%) | 0.137 |
Male | 17096 (50.4%) | 11904 (50.2%) | 5192 (51.1%) | |
Race | ||||
Black | 4126 (12.2%) | 2862 (12.1%) | 1264 (12.4%) | 0.601 |
Other | 2294 (6.77%) | 1615 (6.81%) | 679 (6.68%) | |
White | 27473 (81.1%) | 19248 (81.1%) | 8225 (80.9%) | |
Marital status | ||||
Married | 18836 (55.6%) | 13196 (55.6%) | 5640 (55.5%) | 0.805 |
Unmarried | 15057 (44.4%) | 10529 (44.4%) | 4528 (44.5%) | |
Surgery | ||||
No | 27165 (80.1%) | 19006 (80.1%) | 8159 (80.2%) | 0.791 |
Yes | 6728 (19.9%) | 4719 (19.9%) | 2009 (19.8%) | |
Radiation | ||||
No | 26562 (78.4%) | 18623 (78.5%) | 7939 (78.1%) | 0.401 |
Yes | 7331 (21.6%) | 5102 (21.5%) | 2229 (21.9%) | |
Chemotherapy | ||||
No | 14856 (43.8%) | 10492 (44.2%) | 4364 (42.9%) | 0.027 |
Yes | 19037 (56.2%) | 13233 (55.8%) | 5804 (57.1%) | |
AJCC | ||||
I | 2947 (8.70%) | 2065 (8.70%) | 882 (8.67%) | 0.665 |
II | 12848 (37.9%) | 8943 (37.7%) | 3905 (38.4%) | |
III | 3974 (11.7%) | 2791 (11.8%) | 1183 (11.6%) | |
IV | 14124 (41.7%) | 9926 (41.8%) | 4198 (41.3%) | |
T | ||||
T0 | 11 (0.03%) | 4 (0.02%) | 7 (0.07%) | 0.998 |
T1 | 1259 (3.71%) | 869 (3.66%) | 390 (3.84%) | |
T2 | 6394 (18.9%) | 4463 (18.8%) | 1931 (19.0%) | |
T3 | 16651 (49.1%) | 11668 (49.2%) | 4983 (49.0%) | |
T4 | 6499 (19.2%) | 4558 (19.2%) | 1941 (19.1%) | |
TX | 3079 (9.08%) | 2163 (9.12%) | 916 (9.01%) | |
N | ||||
N0 | 17966 (53.0%) | 12582 (53.0%) | 5384 (53.0%) | 0.625 |
N1 | 12735 (37.6%) | 8932 (37.6%) | 3803 (37.4%) | |
NX | 3192 (9.42%) | 2211 (9.32%) | 981 (9.65%) | |
M | ||||
M0 | 19769 (58.3%) | 13799 (58.2%) | 5970 (58.7%) | 0.352 |
M1 | 14124 (41.7%) | 9926 (41.8%) | 4198 (41.3%) | |
Region | ||||
Alaska | 39 (0.12%) | 30 (0.13%) | 9 (0.09%) | 0.748 |
East | 13443 (39.7%) | 9394 (39.6%) | 4049 (39.8%) | |
Northern Plains | 3611 (10.7%) | 2519 (10.6%) | 1092 (10.7%) | |
Pacific Coast | 15333 (45.2%) | 10739 (45.3%) | 4594 (45.2%) | |
Southwest | 1467 (4.33%) | 1043 (4.40%) | 424 (4.17%) | |
Origin | ||||
Non-Spanish-Hispanic-Latino | 30509 (90.0%) | 21344 (90.0%) | 9165 (90.1%) | 0.361 |
Spanish-Hispanic-Latino | 3384 (9.98%) | 2381 (10.0%) | 1003 (9.86%) | |
Tumor size | ||||
Median(1Q, 3Q) | 37.0(28.0, 50.0) | 37.0(28.0, 50.0) | 37.0(28.0, 50.0) | - |
Tumor extension | ||||
Median(1Q, 3Q) | 440.0(400.0, 600.0) | 440.0(400.0, 600.0) | 440.0(400.0, 600.0) | - |
CS-lymph-nodes | ||||
Median(1Q, 3Q) | 0(0, 110.0) | 0(0, 110.0) | 0(0, 110.0) | - |
CS-mets | ||||
Median(1Q, 3Q) | 0(0, 40.0) | 0(0, 40.0) | 0(0, 40.0) | - |
Status | ||||
Alive | 9685(28.6%) | 6738(28.4%) | 7366(96.4%) | 0.613 |
Dead | 24208(71.4%) | 16987(71.6%) | 275(3.6%) | |
Survival time | ||||
Median(month) | 6.0(2.0, 14.0) | 6.0(2.0, 14.0) | 6.0(2.0, 14.0) | - |
Tab. 1. The basic characteristics of patients with Pancreatic Ductal Adenocarcinoma of the head of the pancreas.
The Hazard Ratio (HR) and 95% Confidence Interval (CI) of each factor related to the OS of patients with PDAC-HP are shown in Table 2. Using cox regression analysis, we screened out independent risk factors that affect the OS of patients with PDAC-HP, such as age at diagnosis (HR=1.01, 95% CI=1.01-1.02, P<0.001), sex (female vs. male: HR=1.07, 95% CI=1.05–1.10, P<0.001), marital status at diagnosis (unmarried vs. married: HR=1.95, 95% CI=1.66–2.28, P<0.001), race (white vs. black: HR=1.12, 95% CI=1.09–1.15, P<0.001), AJCC staging (II vs. I: HR=1.27, 95% CI=1.19–1.35, P<0.001; III vs. I: HR=1.30, 95% CI=1.19–1.41, P<0.001; IV vs. I: HR=1.80, 95% CI=1.60–2.02, P<0.001), surgery (yes vs. no: HR=0.41, 95% CI=0.40–0.41, P<0.001), radiotherapy (yes vs. no: HR=0.91, 95% CI=0.88–0.95, P<0.001), and chemotherapy (yes vs. no: HR=0.46, 95% CI=0.44–0.47, P<0.001). The above 8 variables are incorporated into the final prediction model through AIC criteria. Subsequently, we performed COX survival regression analysis on patients with PDAC-HP to analyze the impact of the selected predictors on the OS of patients. As shown in Figure 2 in the Supplement, the selected predictors had an impact on the OS of patients with PDAC-HP.
Variables | Univariable analysis | Multivariable analysis | ||
---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | |
Age | 1.01 (1.01-1.01) | <0.001*** | 1.01 (1.01-1.02) | <0.001*** |
Sex | ||||
Female | Reference | Reference | ||
Male | 1.02 (1.00-1.05) | 0.059 | 1.07 (1.05-1.10) | <0.001*** |
Race | ||||
Black | Reference | Reference | ||
Other | 0.87 (0.84-0.90) | <0.001*** | 0.93 (0.89-0.96) | <0.001*** |
White | 0.94 (0.88-0.99) | 0.031* | 0.97 (0.91-1.03) | 0.282 |
Marital status | ||||
Married | Reference | Reference | ||
Unmarried | 1.23 (1.20-1.26) | <0.001*** | 1.12 (1.09-1.15) | <0.001*** |
Surgery | ||||
No | Reference | Reference | ||
Yes | 0.33 (0.32-0.34) | <0.001*** | 0.41 (0.40-0.41) | <0.001*** |
Radiation | ||||
No | Reference | Reference | ||
Yes | 0.54 (0.53-0.56) | <0.001*** | 0.91 (0.88-0.95) | <0.001*** |
Chemotherapy | ||||
No | Reference | Reference | ||
Yes | 0.46 (0.44-0.47) | <0.001*** | 0.46 (0.44-0.47) | <0.001*** |
AJCC | ||||
I | Reference | Reference | ||
II | 0.97 (0.93-1.03) | 0.326 | 1.27 (1.19-1.35) | <0.001*** |
III | 1.30 (1.23-1.38) | <0.001*** | 1.30 (1.19-1.41) | <0.001*** |
IV | 2.39 (2.27-2.51) | <0.001*** | 1.80 (1.60-2.02) | <0.001*** |
T | ||||
T0 | Reference | Reference | ||
T1 | 0.33 (0.17-0.65) | 0.001** | 0.63 (0.32-1.22) | 0.17 |
T2 | 0.54 (0.28-1.04) | 0.064 | 0.92 (0.48-1.78) | 0.803 |
T3 | 0.42 (0.22-0.80) | 0.009 | 0.86 (0.45-1.66) | 0.658 |
T4 | 0.55 (0.29-1.06) | 0.074 | 0.89 (0.46-1.72) | 0.734 |
TX | 0.96 (0.50-1.85) | 0.9 | 0.93 (0.48-1.79) | 0.83 |
N | ||||
N0 | Reference | Reference | ||
N1 | 0.91 (0.88-0.93) | <0.001*** | 1.14 (1.1-1.18) | <0.001*** |
NX | 1.81 (1.73-1.89) | <0.001*** | 1.10 (0.96-1.27) | 0.171 |
M | ||||
M0 | Reference | Reference | ||
M1 | 2.30 (2.24-2.36) | <0.001*** | NA | NA |
Region | ||||
Alaska | Reference | Reference | ||
East | 0.71 (0.50-1) | 0.051 | 0.89 (0.63-1.27) | 0.528 |
Northern Plains | 0.74 (0.52-1.04) | 0.087 | 0.93 (0.65-1.32) | 0.674 |
Pacific Coast | 0.74 (0.52-1.04) | 0.085 | 0.86 (0.6-1.22) | 0.385 |
Southwest | (0.79 0.55-1.12) | 0.184 | 0.91 (0.64-1.3) | 0.606 |
Origin | ||||
Non-Spanish-Hispanic-Latino | Reference | Reference | ||
Spanish-Hispanic-Latino | 1.07 (1.02-1.11) | 0.003** | 0.98 (0.94-1.02) | 0.331 |
Tumor size | 1.00 (1.00-1.00) | <0.001*** | 1.00 (1.00-1.00) | 0.395 |
Tumor extension | 1.00 (1.00-1.00) | <0.001*** | 1.00 (1.00-1.00) | 0.412 |
CS_lymph_nodes | 1.00 (1.00-1.00) | <0.001*** | 1.00 (1.00-1.00) | 0.626 |
CS-mets | 1.02 (1.02-1.02) | <0.001*** | 1.00 (1.00-1.00) | 0.621 |
Note: * P<0.05, ** P<0.01, *** P<0.001
Tab. 2. Univariable and multivariable Cox proportional hazard regression analysis of patients with pancreatic ductal adenocarcinoma of the head of the pancreas.
Figure 2: Comparison chart of survival curves of PDAC-HP. (A)Sex: female and male. (B) Race: black, white and others. (C)Marital status: married and unmarried. (D) AJCC stage: I, II, III and IV. (E) Surgery: performed surgery and not performed surgery. (F) Radiotherapy: yes and no. (G) Chemotherapy: yes and no.
Nomogram development
We used the training set to construct the survival prediction nomogram of patients with PDAC-HP through the selected predictors. The C index of the nomogram was 0.736, which was higher than the C index of the AJCC staging system which was 0.625. The nomogram was used to calculate the OS of patients at 1, 3 and 5 years after diagnosis (Figure 1).
Next, we compared the AUCs when using the nomogram and the AJCC staging system to predict the OS of patients with PDAC-HP at 1, 3, and 5 years after diagnosis. The result is shown in Figure 3 in the Supplement. The nomogram predicted that the AUCs of the OS at 1, 3, and 5 years after diagnosis were 0.791, 0.792, and 0.790, respectively. For the AJCC staging system, the AUCs at 1, 3, and 5 years after diagnosis were 0.669, 0.688, and 0.694, respectively.
Finally, we constructed calibration plots to verify the predictive ability of the nomogram. The calibration curves of patients with PDAC-HP at 1, 3, and 5 years showed that the 1, 3, and 5 year survival predictions by the nomogram are very close to the actual survival (Figure 4 in the Supplement).
Figure 3: Comparison of the AUC of nomogram and AJCC staging system in the training set. The AUC is used to predict the overall survival of PDAC-HP at 1-year (A), 3-year (B) and 5-year (C). The red line represents the overall survival predicted by the nomogram, and the blue line represents the overall survival predicted by AJCC staging system.
Figure 4: The calibration plots of the nomogram using the training set. The x-axis represents the overall survival predicted by the nomogram, and the y-axis represents the actual survival. (A) 1-year overall survival. (B) 3-year overall survival. (C) 5-year overall survival.
Nomogram validation
We used the validating set to verify the nomogram, and its index was 0.732, which was higher than the C index of the AJCC staging system (0.623). Then, we compared the AUCs of the both models in the validating set to predict the OS of patients at 1, 3 and 5 years after diagnosis. In the validating set, we found that the AUCs of nomogram for predicting the OS at 1, 3 and 5 years after diagnosis were 0.792(Figure 2A), 0.792 (Figure 2B) and 0.780 (Figure 2C), respectively. It was higher than the AUCs in the AJCC staging system which were 0.670(Figure 2A), 0.680 (Figure 2B) and 0.675 (Figure 2C), respectively (Figure 2).
In addition, we constructed calibration plots on the nomogram for patients in the validating set 1, 3, and 5 years after diagnosis. The results show that the nomogram’s 1-, 3- and 5-year survival predictions were very close to the actual survival (Figure 3).
Finally, we further analyzed the accuracy of the nomogram to predict the OS of patients with PDAC-HP. Compared with the AJCC staging system, the nomogram has better NRI and IRI values. In the nomogram, the NRIs for 1, 3 and 5 years were 0.578 (95% CI=0.551–0.598), 0.398 (95% CI=0.364-0.435), and 0.386 (95% CI=0.338–0.451), respectively; the IDIs for 1, 3 and 5 years were 0.011 (P=0.003), 0.014 (P<0.001), and 0.014 (P<0.001), respectively. Meanwhile, the DCA curves of the nomogram for the validating set at 1, 3, and 5 years after diagnosis are shown in Figure 5 in the supplement. The results show that compared with the AJCC staging system, the nomogram has better accuracy and clinical validity in predicting the OS of patients with PDAC-HP.
Figure 5: The decision curve analysis of the nomogram and the AJCC staging system in the validating set. The decision curve analysis for predicting the prognosis of PDAC-HP at 1-year (A), 3-year (B) and 5-year (C). The black dotted line represents the nomogram, and the red dotted line represents the AJCC staging system. Note:
Discussion
In recent years, there have been about 18 million new cancer cases worldwide each year, and about 9.6 million patients died of cancer [1]. There are approximately 460,000 new cases of pancreatic cancer each year, accounting for 2.5% of all tumors and ranking 14th among new cancers worldwide [1]. Pancreatic cancer includes Pancreatic Ductal Adenocarcinoma (PDAC) and other types, which was the digestive system cancer with the highest mortality rate, with a 5-year survival rate of about 8% [19,20]. Because PDAC is prone to metastasis, various treatments such as surgery, radiotherapy and chemotherapy are little effective, which often has a serious impact on the survival of patients [21,22]. Therefore, early detection of cancer and effective treatment can effectively improve the treatment effect of patients. At present, the TNM staging system is the most widely used tool for evaluating the prognosis of cancer patients, but due to its own limitations, it is unable to make individualized predictions for cancer patients themselves [13,23,24]. Therefore, the development of an individualized predictive model that integrates multiple predictive factors is of great significance for improving the treatment effect of PDAC patients and prolonging the survival period of patients.
A nomogram is a new type of prediction model that can predict the survival rate of a specific outcome [14]. It can combine a variety of predictive factors, such as demographic and tumor characteristics, and graphically display the survival rate of each patient [25]. Accumulating studies have shown that compared with AJCC staging system, nomogram has better predictive ability [26,27]. At present, nomogram is widely used to predict the survival outcome of patients with various tumors, such as lung cancer, breast cancer, and liver cancer [28-30].
In this study, we constructed a nomogram of the survival outcomes of patients with PDAC-HP based on 33,893 American patients with PDAC-HP in the SEER database. The results of the study showed that eight variables proved to be independent prognostic factors, including age at diagnosis, sex, race, marital status at diagnosis, AJCC staging, surgery, radiotherapy and chemotherapy. Through the AIC criteria, we finally determined these eight variables as the predictors of the final nomogram model. In the training set, the C index of the nomogram we constructed is 0.736, which was higher than the C index of the AJCC staging system (0.625). Compared with the AJCC staging system, the nomogram model predicts a higher AUCs for the OS of patients at 1, 3 and 5 years. The results of the calibration plots also showed that the nomogram predicted the expected survival rate of patients with PDAC-HP was very close to the actual survival rate. It shows that the nomogram can predict the survival outcome of patients with PDAC-HP well, and the predictive ability is better than the AJCC staging system.
In the validatiing set, we validated the nomogram for patients with PDAC-HP survival. The C index of the nomogram for the validatiing set (0.732) was similar to the C index of the training set, but was higher than that of the AJCC staging system (0.623). The results of the AUCs and calibration curve of the nomogram showed that the nomogram of the validatiing set could also predict the survival outcome of patients with PDAC-HP well. Then, in order to further evaluate the predictive ability and clinical significance of the nomogram, we analyzed the NRI, IDI and DCA of the nomogram. The NRI and IDI are evaluation indicators of model effectiveness [31-33]. Compared with the AJCC staging system, the NRI and IDI of the nomogram were higher at 1, 3 and 5 years after diagnosis. DCA is generally considered to be useful for verifying the benefits and clinical effectiveness of the model [34-36]. In our study, the nomogram has better DCA results than the AJCC staging system34 at 1, 3 and 5 years after diagnosis. This shows that compared with the AJCC staging system, the nomogram is more clinically effective and accurate in predicting the OS of patients with PDAC-HP. In short, in predicting the OS of patients with PDAC-HP, the nomogram we constructed is better than the AJCC staging system, and provides a reference for patient treatment strategies.
This study still has some limitations that should be noted. First of all, the study is a retrospective study based on the SEER database. Some factors that may affect the OS of patients are not included in the nomogram, such as religious beliefs, education level, lymphovascular invasion, drug treatments. Second, the retrospective research has its own limitations, such as selection and information bias in the selection process of the research set. In addition, the nomogram only includes some predictors, and there may be some deviations when doctors predict the OS of patients. Finally, the data of this study only included the PDAC-HP population in some parts of the United States, and it was concluded that more large independent sets should be added for verification when it is promoted.
Conclusion
In summary, we screened and identified eight predictors related to the OS of patients with PDAC-HP, such as age at diagnosis, sex, race, marital status at diagnosis, AJCC staging, surgery, radiotherapy, and chemotherapy. We established a nomogram of patients with PDAC-HP based on a large research set to predict the OS of patients at 1, 3, and 5 years after diagnosis. The performance of the nomogram we constructed is better than that of the AJCC staging system, and can predict the OS of patients with PDAC-HP well.
Acknowledgements
For the completion of my research, first, I wish to express my deepest gratitude to Prof. Cai, who has given me the most valuable suggestions and advices, and made necessary corrections. Then I am greatly indebeted to Doc. Yu, and Doc. Cao for his advice on the format and help with my computerization. Finally, I would like to express my thanks to my colleagues Doc. Li who have generously offered their help with my study.
Ethical approval
The data of this study comes from the SEER database. The SEER database is a tumor-related database developed by the National Cancer Institute of the United States, providing research data for researchers free of charge. All patients participating in the study received the ethical approval sought by the National Cancer Institute. The informed consent was obtained from all patients or, if patients are under 18, from a parent and/or legal guardian.
Consent for Publication
Consent for publication was obtained from all participants.
Availability of Data and Materials
We obtained permission to access the database after signing and submitting the SEER Research Data Agreement form via email. The data that support the findings of this study are available from SEER database but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of SEER database.
Data Sharing
The datasets generated and analyzed during the current study are available in the SEER database repository (https://seer.cancer.gov).
Conflicts of Interest
None.
Funding
None.
Author Contributions
All authors had full access to all of the data in the study.
Doc. Zhilong Liu, Haohui Yu and Ke Cai take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Ke Cai, Zhilong Liu.
Acquisition, analysis, or interpretation of data: Zhilong Liu, Haohui Yu.
Drafting of the manuscript: Zhilong Liu, Haohui Yu, Mingrong Cao, Ke Cai.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Zhilong Liu, Haohui Yu.
Administrative, technical, or material support: Ke Cai, Mingrong Cao, Jiexing Li.
Supervision: Ke Cai.
All authors contributed to writing of the manuscript and approved the final version
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