Znaczenie systemu antyoksydacyjnego w różnych schorzeniach ginekologicznych – przegląd piśmiennictwa

Abstract

Author(s): Anita Olejek, Jacek ZamlyÅ?ski, Agnieszka Jurek, Piotr Bodzek, Bogdan Szymala, Leszek Nowak

Oxidative stress is due to a disturbance in the balance between the production of reactive oxygen species and the efficiency of the antioxidant defense. Oxidative stress has been implicated in playing a crucial role in the pathogenesis of many diseases, including gynecological disorders, aging and in the initiation and progression of cancer. Reactive oxygen species may modify and inactivate proteins, lipids, DNA, RNA and induce cellular dysfunctions. To prevent free radical- induced cellular damage, the organism has developed the antioxidative system. Antioxidants can generally be divided into two categories: enzymatic and non-enzymatic. In the present study, we describe the changes of antioxidant enzyme activities in many gynecological disorders.

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