WPLYW CETUKSYMABU NA PROCES APOPTOZY I FAZY CYKLU KOMOREK RAKA PIERSI IN VITRO

Abstract

Author(s): Jolanta Rzymowska, Agnieszka Zbyrad

The aim of the study was to check how cetuximab affects the cell cycle and apoptosis of breast cancer cells. The study was conducted on primary breast cancer cell lines and non-neoplastic cell lines derived from samples collected from patients with histopathologically diagnosed Tp1-2 Np0 Mp0 ductal carcinoma. The effect of this chemotherapeutic agent on cells in the G1, S, G2/M cell cycle phases and on apoptosis of these cells was analyzed in a flow cytometer. Cetuximab, a monoclonal antibody, at a dose of 10 and 100 μg/mL of the culture medium was used for the study. Cetuximab is capable of inducing apoptosis and inhibiting cancer cells in the S, and G2/M cell cycle phases. This cytostatic agent can constitute a potential strategy in phase-dependent treatment of breast cancer. However, it is not effective enough to be used in monotherapy.

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Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh

     

     

     

  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis

     

  • Fava Maria Giovanna

     

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