Warto???? prognostyczna nadekspresji receptora HER-2 w raku piersi
Author(s): A BRZOZOWSKA, M MAZURKIEWICZ
Introduction: The aim of this study is evaluation of the prognostic value of HER2 receptor’s overexpression in patients operated on for breast cancer.
Material and methods: 90 patients with breast cancer are included, in whom a radical mastectomy was done between the years 1995-1997 in the Oncological Center of the Lublin District. In every case quantity of HER2 receptors was estimated through immunohistochemical staining. The “3+” result was referred to as overexpression in the stained tissue HER2(+). Overall survival time and disease free time were counted, as well as the probability of a 10-year survival and disease free survival.
Results: Mean overall survival and disease free survival were as follows: 6,3 yrs (75,6+/-29,0 months) and 5,5 yrs (66+/-35,0 months). The probability of 3-, 5-and 10-year overall and disease free survival was 93%, 82%, 77% and 80%, 72%, 65%. HER2 receptors overexpression was diagnosed in 18 patients (20%). Probability of overall 10-year survival in HER2(+) was 55%, while in HER2(-) 85% (p=0,0134). Probability of a 10-year disease free survival was 60% in HER2(+) and almost 70% in HER2(-) (p=0,6317).
Conclusions: Overexpression of HER2 is an adverse prognostic factor for patients overall survival, while making no difference in disease free survival time.<
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Prof. Elhadi Miskeen
Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia
Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
Fava Maria Giovanna
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