Wartość prognostyczna nadekspresji receptora HER-2 w raku piersi



Introduction: The aim of this study is evaluation of the prognostic value of HER2 receptor’s overexpression in patients operated on for breast cancer.

Material and methods: 90 patients with breast cancer are included, in whom a radical mastectomy was done between the years 1995-1997 in the Oncological Center of the Lublin District. In every case quantity of HER2 receptors was estimated through immunohistochemical staining. The “3+” result was referred to as overexpression in the stained tissue HER2(+). Overall survival time and disease free time were counted, as well as the probability of a 10-year survival and disease free survival.

Results: Mean overall survival and disease free survival were as follows: 6,3 yrs (75,6+/-29,0 months) and 5,5 yrs (66+/-35,0 months). The probability of 3-, 5-and 10-year overall and disease free survival was 93%, 82%, 77% and 80%, 72%, 65%. HER2 receptors overexpression was diagnosed in 18 patients (20%). Probability of overall 10-year survival in HER2(+) was 55%, while in HER2(-) 85% (p=0,0134). Probability of a 10-year disease free survival was 60% in HER2(+) and almost 70% in HER2(-) (p=0,6317).

Conclusions: Overexpression of HER2 is an adverse prognostic factor for patients overall survival, while making no difference in disease free survival time.

Share this article

Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

Google Scholar citation report
Citations : 61

Onkologia i Radioterapia received 61 citations as per Google Scholar report

Onkologia i Radioterapia peer review process verified at publons
Indexed In
  • Scimago
  • MIAR
  • Euro Pub
  • Google Scholar
  • Medical Project Poland
  • Cancer Index
  • Gdansk University of Technology, Ministry Points 20