Treatment-free remission in Chronic Myeloid Leukemia (CML): experience of basra hematology center
Abstract
Author(s): Ali Khazaal Jumaa*, Asaad Abdulameer Khalaf, Hasson Mahdi Hasson, Qutaiba Muslim Dawood and Zaynab Raad Qasim
Improved survival rates in Chronic Myeloid Leukaemia (CML) lead to increasing prevalence of the disease, increasing cost and burden on health care systems. The current study aimed to assess the outcome of CML patients that maintained a durable molecular response, after TKI stopping in Iraq. The study enrolled 18 patients with CML who were treated for more than 5 years with Tyrosine Kinase Inhibitors (TKIs) and got a Major Molecular Response (MMR) for 2 years. All patients were subjected to close follow-up after stopping TKI with PCR every 3 months to monitor molecular response. Median age of 45-year, median duration of disease before stopping TKI was the 93-month and median duration of MMR was 37-month. During a median duration of 24 months of follow-up after TKI stopping, 13 patients (72%) succeeded to maintain MMR, while 5 patients (28%) did not. The molecular relapse occurred during the first year of follow up and all 5 patients succeeded to reach MMR (bcr-abl ≤ 0.1%) 3 months after resuming TKI. There was no significant impact of age and duration of treatment and MMR before TKI stopped on treatment-free remission. Treatment-free remission for at least 2 years was found among 70% of the studied patients. Molecular relapses typically occurred within 12 months of TKI discontinuation, and patients quickly regained their molecular response upon retreatment with the same TKI.
Share this article
Editors List
-
Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
-
Sudhakar Tummala
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
-
Alphonse Laya
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
-
Fava Maria Giovanna
- Manuprasad Avaronnan
Google Scholar citation report
Citations : 558
Onkologia i Radioterapia received 558 citations as per Google Scholar report
Onkologia i Radioterapia peer review process verified at publons
Indexed In
- Directory of Open Access Journals
- Scimago
- SCOPUS
- EBSCO A-Z
- MIAR
- Euro Pub
- Google Scholar
- Medical Project Poland
- PUBMED
- Cancer Index
- Gdansk University of Technology, Ministry Points 20