Tolerancja i powiklania paliatywnej teleradioterapii terenu klatki piersiowej chorych na zaawansowanego, niedrobnokomórkowego raka pluca. Analiza 1350 chorych


Author(s): Tomasz Walasek, Marian Reinfuss, Jerzy Jakubowicz, Pawel Blecharz, Piotr Skotnicki, Magdalena PÄ?cak, Piotr Brandys, Elżbieta Pluta, Tomasz DÄ?browski

Purpose: The aim of this study was to evaluate of side effects related to teleradiotherapy of the chest in patients with advanced non-small cell lung cancer, based on analysis of own clinical data.

Methods and materials: In this study a group of 1350 patients after two courses of radiotherapy to a dose of 20 Gy in 5 fractions during 5 days each , separated by a 4-week interval were analyzed .Acute tolerance of this treatment and early toxicity were evaluated. In the group of patients who survived 2 years from the beginning of radiotherapy , the frequency and type of late side effects were assessed.

Results: 92 % of studied patients completed treatment as planned . Early toxicity was found in 64 (4,7%) of the patients. In 7 (9,7 %) out of 76 patients who survived 2 years after radiotherapy lung cirrhosis with respiratory insufficiency was found.

Conclusions: Chest irradiation with two courses of radiotherapy of 20 Gy given in 5 fractions during 5 days each separated by 4-week interval is a well tolerated method of palliative treatment in patients with advanced non-small lung cancer. The most common acute complications were: pneumonitis and oesophagitis, persistent vomiting and nausea lung hemorrhage. The most common late side effect is pneumocirrhosis.

Share this article

Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

Google Scholar citation report
Citations : 61

Onkologia i Radioterapia received 61 citations as per Google Scholar report

Onkologia i Radioterapia peer review process verified at publons
Indexed In
  • Scimago
  • MIAR
  • Euro Pub
  • Google Scholar
  • Medical Project Poland
  • Cancer Index
  • Gdansk University of Technology, Ministry Points 20