Tolerancja i powiklania paliatywnej teleradioterapii terenu klatki piersiowej chorych na zaawansowanego, niedrobnokomórkowego raka pluca. Analiza 1350 chorych

Abstract

Author(s): Tomasz Walasek, Marian Reinfuss, Jerzy Jakubowicz, Pawel Blecharz, Piotr Skotnicki, Magdalena Pęcak, Piotr Brandys, Elżbieta Pluta, Tomasz Dąbrowski

Purpose: The aim of this study was to evaluate of side effects related to teleradiotherapy of the chest in patients with advanced non-small cell lung cancer, based on analysis of own clinical data.

Methods and materials: In this study a group of 1350 patients after two courses of radiotherapy to a dose of 20 Gy in 5 fractions during 5 days each , separated by a 4-week interval were analyzed .Acute tolerance of this treatment and early toxicity were evaluated. In the group of patients who survived 2 years from the beginning of radiotherapy , the frequency and type of late side effects were assessed.

Results: 92 % of studied patients completed treatment as planned . Early toxicity was found in 64 (4,7%) of the patients. In 7 (9,7 %) out of 76 patients who survived 2 years after radiotherapy lung cirrhosis with respiratory insufficiency was found.

Conclusions: Chest irradiation with two courses of radiotherapy of 20 Gy given in 5 fractions during 5 days each separated by 4-week interval is a well tolerated method of palliative treatment in patients with advanced non-small lung cancer. The most common acute complications were: pneumonitis and oesophagitis, persistent vomiting and nausea lung hemorrhage. The most common late side effect is pneumocirrhosis.

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