Tolerancja i powiklania paliatywnej teleradioterapii terenu klatki piersiowej chorych na zaawansowanego, niedrobnokom�rkowego raka pluca. Analiza 1350 chorych
Author(s): Tomasz Walasek, Marian Reinfuss, Jerzy Jakubowicz, Pawel Blecharz, Piotr Skotnicki, Magdalena PÄ?cak, Piotr Brandys, ElÅ¼bieta Pluta, Tomasz DÄ?browski
Purpose: The aim of this study was to evaluate of side effects related to teleradiotherapy of the chest in patients with advanced non-small cell lung cancer, based on analysis of own clinical data.
Methods and materials: In this study a group of 1350 patients after two courses of radiotherapy to a dose of 20 Gy in 5 fractions during 5 days each , separated by a 4-week interval were analyzed .Acute tolerance of this treatment and early toxicity were evaluated. In the group of patients who survived 2 years from the beginning of radiotherapy , the frequency and type of late side effects were assessed.
Results: 92 % of studied patients completed treatment as planned . Early toxicity was found in 64 (4,7%) of the patients. In 7 (9,7 %) out of 76 patients who survived 2 years after radiotherapy lung cirrhosis with respiratory insufficiency was found.
Conclusions: Chest irradiation with two courses of radiotherapy of 20 Gy given in 5 fractions during 5 days each separated by 4-week interval is a well tolerated method of palliative treatment in patients with advanced non-small lung cancer. The most common acute complications were: pneumonitis and oesophagitis, persistent vomiting and nausea lung hemorrhage. The most common late side effect is pneumocirrhosis.<
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Prof. Elhadi Miskeen
Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia
Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
Fava Maria Giovanna
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