The Physical Parameters Variation Related to the Standard Uptake Value and Mass Activity in the Benign and Malignant Adrenal gland
Background: This study is to evaluate the benign and malignant of adrenal mass using physics parameters of standard uptake value and mass activity through pet/CT scan.
Materials and Methods: The study involved 47 patients which were diagnosed with adrenal gland tumors by a nuclear medicine physician. Before the PET/CT scan, patients must adhere to specific fasting protocols, including abstaining from carbohydrates and sugars for 12 hours and from food for 6 hours. However, they were being permitted to consume water. Patient is injected intravenously by 18-FDG with 0.1 mci per kilogram of body weight. The volume of interest (VOI) and Region of interest (ROI) was determined manually or semi-automatically. The physics parameters used in this study are Adrenal Mass Activity 3D and 2D (MBq), Adrenal Max SUVs (MBq/ml)
Results: According to the Pet /CT scan image, blood test and adrenal biopsy, the patients were divided into two groups based on tumor type: 38 patients had malignant, and nine were benign. Patients in benign and malignant groups showed no significant differences in age, gender, height, weight, BMI, glucose level, fasting duration, and FDG-18 dose. The Adrenal Mass Activity 3D (MBq) for the malignant group was significantly higher than the benign group, and the maximum adrenal standard uptake values (SUV) were significantly higher. A correlation test was conducted between the injected Dose (ID in MBq) of FDG-18 and the three parameters: 3 Dimensions, Adrenal mass activity in 2 Dimensions (MBq), and the maximum standard uptake values (SUV) (MBq/ ml). The analysis showed no significant correlation between the ID and the 3 Dimensions, 2 Dimensions, or SUV for both malignant and benign.
Conclusions: The variation in standard uptake value and activity of FDG-18 can be added as a physical parameter to differentiate between benign and malignant in adrenal mass diagnostic.
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Prof. Elhadi Miskeen
Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia
Ahmed Hussien Alshewered
University of Basrah College of Medicine, Iraq
Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh
Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis
Fava Maria Giovanna
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