The necessity of preoperative evaluation of endometrial cancer metastasis for management plan using CT scan: Scoping systematic review


Author(s): Salwa Masad S Alenzi* and Daniyah Ibrahim Badrun

Background: Endometrial cancer is the most common gynaecologic malignancy, and the accurate evaluation of metastasis is crucial for the optimal management plan. CT scan is a widely used imaging modality to evaluate endometrial cancer.

Objective: This systematic review aims to evaluate the diagnostic performance of a preoperative CT scan in detecting endometrial cancer metastasis and its impact on the surgical management plan.

Methods: We conducted a comprehensive literature search in various electronic databases, including PubMed, Embase, and Cochrane Library, from inception to September 2021. We included studies that evaluated the diagnostic accuracy of CT scans for the detection of endometrial cancer metastasis. Two independent reviewers screened the articles, extracted data, and assessed the quality of the studies.

Results: 14 studies met the inclusion criteria, including 2417 patients. The pooled sensitivity and specificity of CT scan for the detection of metastasis were 86% (95% CI, 79%-91%) and 95% (95% CI, 91%-97%), respectively. The positive likelihood ratio was 15.9 (95% CI, 8.1-31.2), and the negative likelihood ratio was 0.15 (95% CI, 0.09-0.23). The CT scan significantly impacted the surgical management plan in 69% of patients.

Conclusion: Preoperative evaluation of endometrial cancer metastasis using a CT scan is essential for the optimal management plan. CT scan has high diagnostic accuracy in detecting metastasis, and it significantly impacts the surgical management plan. Therefore, it should be included in the standard workup of patients with endometrial cancer.

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Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


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