The efficiency of standard uptake value in Pet /CT scan to evaluate the malignant adrenal mass in oncology patients

Abstract

Author(s): Maryam M. Amer* and Nadiya Y. Mohammed

This study is aimed to evaluate the malignant adrenal mass existing in the both sides of the body using the Standard Uptake Value (SUV), 2D activity mass and 3D activity mass of adrenal gland. Materials and Methods: This study included 47 patients who had adrenal mass diagnosed by a physician specializing in nuclear medicine. Prior to the PET/ CT scan, patients were asked to adhere to certain fasting procedures, which include abstaining from carbohydrates and sweets for 12 hours and abstaining from meals for 6 hours, with the exception of water. In addition, patients were instructed to reduce strenuous activity and to discontinue insulin therapy. The SUV was evaluated by making an elliptical Region of Interest (ROI), a minimum of two thirds of the adrenal mass on the fused PET/CT image. Three-dimensional and two-dimensional adrenal mass activity was investigated as physical variables in this research. Results: There was no statistically significant difference between the right and left malignant adrenal mass for the three parameters, adrenal mass activity in 2-dimensions (2D), adrenal mass activity in 3- dimensions (3D) and the maximum Standardized Uptake Values (SUV). The 3D and 2D adrenal mass activity of the right malignant mass was greater than that of the left mass. Statistical results revealed a significant negative association between the injected dose and adrenal mass activity in a 3D in the right adrenal gland. In contrast, the results of this study revealed no significant association between activity mass of adrenal gland in the both sides and the maximum standard uptake value. In addition to the proportion of left adrenal mass, there was a strong positive correlation between 2D and 3D adrenal mass activity identified with the dose injected with FDG-18. Consistently, the data revealed no correlation between the SUV value of left adrenal mass and the injected dose. Conclusion: Positron Emission Tomography (PET/CT) can enhance the diagnosis of the malignant adrenal mass on both sides of the body. The right malignant activity and the SUV standard uptake value are higher than the left affected by the injected dose of FDG-18.

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