The effect of He-Ne laser and gold nanoparticles on expression of TGF beta in mice mammary adenocarcinoma

Abstract

Author(s): Farah AJ Al-Zahawi*, Zainab M Alawad and Hanan L AL-Omary

Cancer cases are increasing all over the world due to many reasons; Transforming Growth Factor Beta (TGFβ) is a cytokine that plays a significant role in immunoregulation, cancer, and angiogenesis. The aim of the study was to examine the effects of He-Ne laser and Gold Nanoparticles (AuNPs) on TGF beta expression in mice with mammary adenocarcinoma. Fourteen albino female mice were selected, their ages were 3 to 4 weeks while their weights were ranged from 15 to 20 gm, and they were recruited from the Iraqi center for cancer and medical genetic research. The colloidal gold nanoparticles were prepared in a certain concentration and specifications, while Low Level Laser (LLL) was adjusted in a certain wavelength and power density. The tissue was taken from the breast of albino mice that are affected by adenocarcinoma, one group of the albino mice (7 mice) were irradiated by laser, while the other group (7 mice) was injected with the colloidal solution of nanogold particles. A low concentration of nanogold did not show any effect, thus only high concentration was used in the current study. LLL Therapy (LLLT) has more effect on TGFβ than nanogold by about 10%, however, the difference was not significant. The study came up with certain findings among them are; LLLT and AuNPs are used in cancer treatment, only high concentration of nanogold has effect on TGF-Beta. LLLT has more effect on TGF-Beta and is more active than nanogold.

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