Superoxide dismutase activity in breast cancer patients treated with anastrozole

Abstract

Author(s): Hamed A. Hasan, Ali Waleed Al-Ani

Anastrozole is an endocrine therapy which has been used for treatment of breast cancer patients. This study aimed to investigate the effect of anastrozole on superoxide dismutase (SOD) isoforms, include Cu/Zn-SOD and Mn-SOD, in postmenopausal women with breast cancer. This study included 70 postmenopausal women with breast cancer, including 40 untreated women with new diagnosed breast cancer (BC group) as well as 30 additional breast cancer women who received anastrozole therapy for three years (anastrozole group). Thirty postmenopausal women were categorized as healthy (control group). Our results showed a significant increase in SOD concentration of anastrozole group compared to BC and control groups. SODs activities (Cu/Zn-SOD and Mn-SOD) were decreased in anastrozole group compared to BC and control groups. SOD specific activities were increased under anastrozole treatment compared to BC group. We can conclude that the expression of SOD might be increased in BC patients as a response of free radical accumulation, However, not all of the SODs are expressed in active form. Furthermore, our data suggested that the treatment with anastrozole might be contributed in the improvement of the expression of activated SODs.

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