Study anticancer and antioxidant activity of the prepared compound 2-methoxy-4-{(E)-[2-(5-sulfanyl-1, 3,4-thiadiazol-2yl)hydrazinylidene]methyl}phenol

Abstract

Author(s): Safaa.H. Nasir, Ibrahim. A. Flifel

The current study paid attention to the preparation of a chemical compound, 2-methoxy-4-{(E)-[2-(5-sulfanyl-1,3,4-thiadiazol 2yl)hydrazinyli dene]methyl}phenol and its complexes. This ligand was used as an anticancer agent, as it gave high efficacy when tested on normal cells and cancer cells. This compound was also used as an antioxidant when compared with vitamin C. It was found to have high efficacy at low concentrations. This study included three axes, the first axis synthesis of chemical compound (2-methoxy-4-{(E)-[2-(5-sulfanyl-1,3,4-thiadiazol 2yl)hydrazinylidene]methyl}phenol )and its complexes with Ni(??), Cu(??), Fe(???), Cr(???) ions and characterization by mass spectra, 1HNMR and FTIR. The hyper-chem study of transition metal complexes suggests octahedral geometry for Fe+3 and Cr+3 ion, square planer geometry for Ni+2, and Cu+2, suggesting tetrahedral geometry. In the second step, the ligand was tested as an anticancer activity also, In the third step the ligand was tested as an antioxidant activity the prepared ligand showed good anticancer, and antioxidant activity

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