Study anticancer and antioxidant activity of the prepared compound 2-methoxy-4-{(E)-[2-(5-sulfanyl-1, 3,4-thiadiazol-2yl)hydrazinylidene]methyl}phenol


Author(s): Safaa.H. Nasir, Ibrahim. A. Flifel

The current study paid attention to the preparation of a chemical compound, 2-methoxy-4-{(E)-[2-(5-sulfanyl-1,3,4-thiadiazol 2yl)hydrazinyli dene]methyl}phenol and its complexes. This ligand was used as an anticancer agent, as it gave high efficacy when tested on normal cells and cancer cells. This compound was also used as an antioxidant when compared with vitamin C. It was found to have high efficacy at low concentrations. This study included three axes, the first axis synthesis of chemical compound (2-methoxy-4-{(E)-[2-(5-sulfanyl-1,3,4-thiadiazol 2yl)hydrazinylidene]methyl}phenol )and its complexes with Ni(??), Cu(??), Fe(???), Cr(???) ions and characterization by mass spectra, 1HNMR and FTIR. The hyper-chem study of transition metal complexes suggests octahedral geometry for Fe+3 and Cr+3 ion, square planer geometry for Ni+2, and Cu+2, suggesting tetrahedral geometry. In the second step, the ligand was tested as an anticancer activity also, In the third step the ligand was tested as an antioxidant activity the prepared ligand showed good anticancer, and antioxidant activity

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Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


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