Rola ukladu immunologicznego w rozwoju nowotworów zlośliwych – stary problem, nowe spojrzenie

Abstract

Author(s): Pawel Rybojad, Andrzej Jablonka, Krzysztof Paprota, Jacek Tabarkiewicz

Since the beginning of the nineteenth century, there have been reports about the possible involvement of the immune system in inhibiting of tumor growth. The starting point for research on tumor immunology is the fact that during malignant transformation each cell gains new antigenenic properties (different from the natural ones) which stimulates the immune system. Despite extensive knowledge, the role of the individual components of the immune system in host- neoplasm relationship is not fully specified. Its effectiveness is often inefficient because of tumor cells’ contrreaction, which in order to prevent tumor’s elimination by the host’s organism, evolved defensive reactions. Analysis of tumor growth at the level of cellular cytochemistry, determination of the disorders of the relationship between every stage of immune response, seems to be the basis for further understanding of the process of cancer’s development and progress. Intensive research in this field are carried out all over the world. More recent discoveries show that immunology may become the key to faster diagnosis, monitoring and perhaps definitive cancer treatment.

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