Radiotherapy-induced changes in high-density lipoproteins: implications for alzheimer's disease and oncology

Abstract

Author(s): Nadia Abd Ellatif Ali, Abed Sultan Hassan, Mohamed Ghassan Adeeb

High-Density Lipoproteins (HDL) have an important role in the balance of cholesterol in the human body. Especially Apoliprotein E (APOE) the E4 allele, which is a major risk factor of Alzheimer's disease, yet we must not forget the fact that it is a major protein with a strong affinity for High-Density Lipoprotein (HDL), as it is involved in the transport of lipids in both the peripheral and central nervous systems of the body. So, the aim must be defined, which is to determine the effect of the APOE genotype on HDL function Volume in the context of Alzheimer's disease. This case-control study includes 114 subjects, 60 controls and 54 patients to fulfill the aim of study. High-density lipoproteins are one of the elements that cause cognitive impairment and Alzheimer's so that, calculation and measurement of Cholesterol Efflux Capacity (CEC) as well as Lecithin and Cholesterol Acyltransferase (LCAT) activity were done, in addition to the neurological and psychological tests in order to classify the type of dementia, magnetic resonance imaging have used to determine whether cognition is related to HDL function and size. Results showed the predominance of the ε3 allele in the sick group with frequency of the aisle ε4 in our study is twice as high in the sick group (27.80%) as in the control group (12.3%) showing a variation of 15.5%; it reaches a peak in the age group of 70years-79 years. Because the size of HDL plays an important role in determining the degree of disease and how to fight it. As all evidence indicates that High-Density Lipoprotein (HDL) particles in the Central Nervous System (CNS) and afferents are the main etiology of Alzheimer's disease. We were able to determine whether HDL CEC and LCAT activity were altered within a large group of APOE genetic proteins.

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