Radiobiologia w radioterapii hipofrakcjonowanej

Abstract

Author(s): Izabela Wiatrowska, Renata Kabacinska, Judyta Lasota, Roman Makarewicz

Linear Quadratic Model is the most widely used mathematical formula to assess the impact of changes in fractionation scheme on the outcome of the overall therapeutic index. It is also used to predict the biological effect in tissue treated with ionizing radiation during radiotherapy, and in determining the risk doses for healthy tissues. An important factor in the LQ model is the α/ß ratio, which describes the ability to repair tissues and their sensitivity to change in fractional doses. The cells characterized by a low α/ß coefficient are sensitive to a large extent to the fractional change in dose. This is an attribute of some types of cancer in which the optimal method of treatment is hypofractionation.

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