Radiobiologia w radioterapii hipofrakcjonowanej


Author(s): Izabela Wiatrowska, Renata Kabacinska, Judyta Lasota, Roman Makarewicz

Linear Quadratic Model is the most widely used mathematical formula to assess the impact of changes in fractionation scheme on the outcome of the overall therapeutic index. It is also used to predict the biological effect in tissue treated with ionizing radiation during radiotherapy, and in determining the risk doses for healthy tissues. An important factor in the LQ model is the α/ß ratio, which describes the ability to repair tissues and their sensitivity to change in fractional doses. The cells characterized by a low α/ß coefficient are sensitive to a large extent to the fractional change in dose. This is an attribute of some types of cancer in which the optimal method of treatment is hypofractionation.

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Editors List

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

  • Krzysztof Urbanski

    Head of the Oncology Gynecology Clinic, Oncology Center - Instytut im. Maria Sklodowska Curie, Department in Krakow (Krakow, Poland)

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Citations : 33

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