Radiation-induced sarcoma in thyroid: about a case report and review of the literature


Author(s): Abboud Fatima Zahra*, Bouziane Amina, Ait Erraisse Mohamed, Youssoufi Moulay Ali, Zoukal sofia, Bouhafa Touria, Hassouni Khalid

Introduction: Sarcomas in irradiated areas are rare diseases with an unfavorable prognosis. If complete tumor resection is the first-line treatment, the place of radiotherapy in a curative approach is not clearly defined. Methods: We report a rare case of Radiation-Induced Sarcoma (RIS) that arose in the thyroid, 27 years after radiotherapy for a localized undifferentiated nasopharyngeal carcinoma (UCNT). The patient was treated in 1992 with radiotherapy and chemotherapy intended to treat curatively. Twenty-seven years after the end of radiotherapy, the patient presented with a sarcoma in thyroid for which she received an initial surgical resection with positive margins followed by adjuvant radiotherapy. Results: The patient presented with a progression of her disease within one month of the end of radiotherapy. Conclusion: The complete surgical resection sarcoma within the irradiated field is often difficult to achieve enhancing the risk of relapse. Radiation therapy should be discussed when faced with an unrespectable tumour or after suboptimal surgery as part of intensified local management with curative intent.

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Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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