Radiation-induced sarcoma in thyroid: about a case report and review of the literature


Author(s): Abboud Fatima Zahra*, Bouziane Amina, Ait Erraisse Mohamed, Youssoufi Moulay Ali, Zoukal sofia, Bouhafa Touria, Hassouni Khalid

Introduction: Sarcomas in irradiated areas are rare diseases with an unfavorable prognosis. If complete tumor resection is the first-line treatment, the place of radiotherapy in a curative approach is not clearly defined. Methods: We report a rare case of Radiation-Induced Sarcoma (RIS) that arose in the thyroid, 27 years after radiotherapy for a localized undifferentiated nasopharyngeal carcinoma (UCNT). The patient was treated in 1992 with radiotherapy and chemotherapy intended to treat curatively. Twenty-seven years after the end of radiotherapy, the patient presented with a sarcoma in thyroid for which she received an initial surgical resection with positive margins followed by adjuvant radiotherapy. Results: The patient presented with a progression of her disease within one month of the end of radiotherapy. Conclusion: The complete surgical resection sarcoma within the irradiated field is often difficult to achieve enhancing the risk of relapse. Radiation therapy should be discussed when faced with an unrespectable tumour or after suboptimal surgery as part of intensified local management with curative intent.

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Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


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