Powiklania neurologiczne u dzieci z ostrą bialaczką limfoblastyczną wylączając wstępne zajęcie OUN

Abstract

Author(s): JOANNA ZAWITKOWSKA, MIROSLAW JASIŃSKI, URSZULA MALEK, JERZY R KOWALCZYK

Introduction: The neurologic comlications in children with acute limphoblastic leukemia (ALL) can be associated with leukemic involvement of CNS nad antileukemic therapy.

Aim of study: This study presents retrospective analyses patients with ALL who developed neurologic complications (except leukemic infiltration). Material and methods. The study group included 86 patients with ALL treated in The Department of Pediatrc Hematology and Oncology UM in Lublin between November 2002 and January 2008. Fifteen children developed neurologic complications. Leukemic infiltration was excluded using cerebrospinal fluid cytology and radiological imaging techniques at diagnosis.

Results: The study group included 6 girls and 9 boys, aged between 1,5 do 17 years. The most common complication was polyneuropathy, which developed in 10 patients. In two patients diagnosed meningitis. Cerebral infarct were detected in two children. Four patients presented convulsions. These complications were observed both during induction and reinduction therapy. Among analysed group, two patients died, remaining completed treatmet or continue maintance.

Coclusion: The neurologic complications in children with ALL were quite variable. It is difficult to say if these were caused by only cytostatic or the same leukemia too. Elucidation of the underlying pathologies of CNS complication in Leukemia children by further studies including neurological tests in larger study groups are necessary.<

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