polymorphism of FGFR2 gene in breast cancer of Iraqi patients

Abstract

Author(s): Zainab Anass Slman1 Mahfoodha Abbas Umran2 Hadeel Kamil Abudhla Alwachi3

The receptor tyrosine kinase Fibroblast Growth Factor Receptor type
2 (FGFR2) is required for the development of several tissues,
including the breast. SNPs in FGFR2 have recently attracted attention
because they constitute a high-risk haplotype linked to an elevated
risk of breast cancer. The high risk SNP haplotype has a greater
affinity for the transcription factor RUNX2, according to this study.
Analysis and quantification of the FGFR2 transcript revealed no
difference in splicing with genotype. It's unknown if a single
polymorphism is responsible or if numerous SNPs are involved.

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