Ocena wyników i metod pooperacyjnego napromieniania złośliwych glejaków mózgu

Abstract

Author(s): BEATA WINKLER, DAGMARA NYCZ-BEDOŃSKA, KATARZYNA KOSIBA-KRUPA

Introduction: The aim of the study was evaluation of results and methods of postoperative irradiation patients suffering on malignant brain gliomas. Retrospective analysis of 206 patients treated in Centrum Onkologii Ziemi Lubelskiej in 1992-2002 has been carried out.

Material and methods: All patients passed operative treatment. In 54% radical operation was performed, 46% of patents underwent palliative operation. The most frequently occurring microscopic form was glioblastoma multiforme - 72%. The patients were treated in conditions of teleradiotherapy with two methods: conventional dose fractionation and unconventional, so called method of “series”.

Results: 5-years-long total survivals were evaluated in examined group of patients. Analysis of 5- year-long total survival rates was performed by Kaplan-Meier’s method. Mean value of survival time amounted to 11.5 months. Survival time of examined patients depends essentially on the method of irradiation. Median of total survival time of conventional dose fractionation method is 11 months while median of total survival time of patients unconventionally irradiated is 6.5 months. Results of postoperative irradiation of malignant brain gliomas are bad.

Conclusions: Method of radiotherapy is a fundamental prognostic factor.

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Editors List

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

  • Krzysztof Urbanski

    Head of the Oncology Gynecology Clinic, Oncology Center - Instytut im. Maria Sklodowska Curie, Department in Krakow (Krakow, Poland)

  • Andrzej Szawlowski

    Klinika Nowotworow Gornego Odcinka Uklad Digestii, Oncology Center - Institute (Warsaw, Poland)

  • Skowronska-Gardas

    Department of Radiotherapy, Oncology Center-Institute (Warsaw, Poland)

  • Serban-Dan Costa

    Head of the Obstetrics and Gynecology Clinic of the University of Otto von Guericke (Magdeburg, Germany)