Ocena tolerancji i skuteczności napromieniania całej wątroby u pacjentów z przerzutami raka jelita grubego

Abstract

Author(s): MARCIN BIAŁAS, JERZY WYDMAÅ?SKI, SŁAWOMIR BLAMEK, RAFAŁ SUWIÅ?SKI

Purpose: The aim of this study was to assess to effectiveness and tolerance of liver irradiation of hepatic metastases from colorectal cancer.

Material and method: Sixty patients (26 women and 34 men, 31-80 years old, median age 60) were treated between 03.1999 and 11.2005 with external beam irradiation. All of them were irradiated with 20 or 6 MV photons with two opposed fields technique to the total dose of 18 Gy in 10 fractions. Thirty eight (63%) of patients previously received chemotherapy according to 5-Fu + LV protocol. 18 (30%) of patients received chemotherapy of the second line. All patients were retrospectively assessed for response, toxicity, and survival.

Results: 59 (98%) of patients completed the treatment, only one patient didn’t complete the treatment because of deterioration of general performance status. The most frequent acute toxicity was mild to moderate nausea, it was observed in 9 (15%) patients. Before treatment 68% of patients suffered from hepatalgia, 5% of patients complained of nausea and 3% of patients of lumbalgia. 36 (60%) of patients demonstrated subjective response. Median duration of palliative effect was 3,8 months (range 1-18 months). Median survival was 8.7 months (range 1-34 months).

Conclusions: Whole liver irradiation due to colorectal metastases can be an effective and safe method of palliation, that might be considered in patients with progression after palliative chemotherapy.

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Editors List

  • S.SREEDHAR

    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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