Ocena obrazów histopatologicznych endometrium u pacjentek z zespolem androgennym z uwzględnieniem wzorca miesiączkowania


Author(s): Ewa Rudnicka, Stanislaw Radowicki

Aim. To evaluate endometrial histological morphology in patients with androgen excess disorders regarding the menstrual pattern.

Material and methods: The material was 231 patients aged 18-35 years (average 23,46 ± 4,38) who were hospitalized in the Gynecologic Endocrinology Department of the Warsaw Medical University due to androgen excess disorders from 2003 to 2005. The patients were divided into 4 groups depending on menstrual pattern, eumenorrhoea (n=66), polymenorrhoea (n=32), oligomenorrhoea (n=93) and secondary amenorrhoea (n=40). The control group was 40 healthy women with normal menstrual patterns and no symptoms of hyperandrogenism. The following data was analyzed in every patient: age, menarche age, body mass index and endometrium histological findings obtained with the Pipelle probe aspiration. Statistic analysis was performed and the values of p<0,05 were assumed to be significant.

Results: Out of 231(100%) patients with androgen excess disorders in 75 (32,47%) secretory endometrium was observed. 30 patients (12,99%) had mixed type endometrium and 117 (50,66%) had proliferative. Aspiration biopsy revealed polypoid endometrium in 6 women (2,59%) and endometrial hyperplasia without cellular atypia in 3 patients (1,29%). In patient with oligomenorrhoea and secondary amenorrhoea proliferative endometrium was observed significantly more often (p<0,001 and p<0,001). Secretory endometrium respectively more seldom in the very study groups (p<0,001 and p<0,001). In patient with normal menstrual cycles secretory endometrium was significantly less frequently detected (p<0,01).

Conclusion: Patients with the androgen excess disorders significantly more frequently present the prolonged proliferative endometrium phase.The performed studies confirm the thesis that with the intensification of the menstrual pattern disorders more often the pathology of the endometrium maturation in women with androgen excess is observed.


Share this article

Awards Nomination

Editors List

  • Prof. Elhadi Miskeen

    Obstetrics and Gynaecology Faculty of Medicine, University of Bisha, Saudi Arabia

  • Ahmed Hussien Alshewered

    University of Basrah College of Medicine, Iraq

  • Sudhakar Tummala

    Department of Electronics and Communication Engineering SRM University – AP, Andhra Pradesh




  • Alphonse Laya

    Supervisor of Biochemistry Lab and PhD. students of Faculty of Science, Department of Chemistry and Department of Chemis


  • Fava Maria Giovanna


Google Scholar citation report
Citations : 208

Onkologia i Radioterapia received 208 citations as per Google Scholar report

Onkologia i Radioterapia peer review process verified at publons
Indexed In
  • Directory of Open Access Journals
  • Scimago
  • MIAR
  • Euro Pub
  • Google Scholar
  • Medical Project Poland
  • Cancer Index
  • Gdansk University of Technology, Ministry Points 20