Ocena obrazˇw histopatologicznych endometrium u pacjentek z zespolem androgennym z uwzgl??dnieniem wzorca miesi??czkowania
Author(s): Ewa Rudnicka, Stanislaw Radowicki
Aim. To evaluate endometrial histological morphology in patients with androgen excess disorders regarding the menstrual pattern.
Material and methods: The material was 231 patients aged 18-35 years (average 23,46 ± 4,38) who were hospitalized in the Gynecologic Endocrinology Department of the Warsaw Medical University due to androgen excess disorders from 2003 to 2005. The patients were divided into 4 groups depending on menstrual pattern, eumenorrhoea (n=66), polymenorrhoea (n=32), oligomenorrhoea (n=93) and secondary amenorrhoea (n=40). The control group was 40 healthy women with normal menstrual patterns and no symptoms of hyperandrogenism. The following data was analyzed in every patient: age, menarche age, body mass index and endometrium histological findings obtained with the Pipelle probe aspiration. Statistic analysis was performed and the values of p<0,05 were assumed to be significant.
Results: Out of 231(100%) patients with androgen excess disorders in 75 (32,47%) secretory endometrium was observed. 30 patients (12,99%) had mixed type endometrium and 117 (50,66%) had proliferative. Aspiration biopsy revealed polypoid endometrium in 6 women (2,59%) and endometrial hyperplasia without cellular atypia in 3 patients (1,29%). In patient with oligomenorrhoea and secondary amenorrhoea proliferative endometrium was observed significantly more often (p<0,001 and p<0,001). Secretory endometrium respectively more seldom in the very study groups (p<0,001 and p<0,001). In patient with normal menstrual cycles secretory endometrium was significantly less frequently detected (p<0,01).
Conclusion: Patients with the androgen excess disorders significantly more frequently present the prolonged proliferative endometrium phase.The performed studies confirm the thesis that with the intensification of the menstrual pattern disorders more often the pathology of the endometrium maturation in women with androgen excess is observed.
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Submitted PhD thesis in Biotechnology at GITAM University, Vizag.
The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
Saudi Arabia Critical Care/TPN
Clinical Pharmacist Ministry of Health,
Riyadh, Saudi Arabia.
Department of Radiation Oncology
Asahi University Hospital
Gifu city, Gifu, Japan
Maher Abdel Fattah Al-Shayeb
Department of Surgical Sciences, Ajman University, UAE
Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)
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