Ocena ekspresji bialek Id2 i gęstości mikronaczyń w różnych typach złośliwych nowotworów jajnika
Author(s): A Czekierdowski, S Czekierdowska, W Bednarek, J DaniÃ ÂoÃ Â, D Morawska
Background. Recent data indicate that inhibitors of DNA binding/inhibitors of differentiation (Id) protein family (Id-1, -2, -3 and -4) proteins may play a significant role in the progression, neoangiogenesis control and metastases formation of various types of malignancies, including ovarian cancer
Aims. Our aim was to assess if the expression of Id2 proteins is associated with selected cinical features and microvessel density in women with malignant ovarian tumors.
Material and methods. The study group included 56 women operated because of ovarian cancer. The findings were correlated with the tumor type, histological grading and tumor FIGO stage. Tumor Id2 protein expression was assessed by immunohistochemistry and microvessel density was examined as CD-34 expression.
Results. The mean age of the patients was 57± 12,8 (SD) years and 37 (66,1%) of women in this group were postmenopausal. Histological examination revealed that there 27 were serous ovarian cancers (n=27), 12 mucinous cancers, 4 endometrioid cancers and 13 other malignant tumors. Expression of Id2 protein estimated semiquantitatively (as 1 to 9 points) was found in 52 cases. Id2 protein was found in both nuclei and cytoplasm of cancer cells, however, some staining was seen in pericytes adjacent to tumor microcapillary lumen. Patients menopausal status had no influence on the intenstity of protein staining. Low FIGO stage (I and II) tumors had medium or high Id2 expression. Microvessel density, but not Id2 expression was significantly correlated with tumor histological type (p=0,008) with the lowest values found in serous tumors and the highest values found in mucinous cancers. A significant correlation between Id2 expression and MVD was found (R=0,38; p=0,003).The median of MVD was almost twice lower in a group of cancers with low when compared to high Id2 protein expression.
Conclusions. Our results indicate that Id2 protein with microvessel density assessment may be used as additional prognostic factors in women with various types of malignant ovarian tumors.
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Department of Radiation Oncology
Asahi University Hospital
Gifu city, Gifu, Japan
Maher Abdel Fattah Al-Shayeb
Department of Surgical Sciences, Ajman University, UAE
Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)
Head of the Oncology Gynecology Clinic, Oncology Center - Instytut im. Maria Sklodowska Curie, Department in Krakow (Krakow, Poland)
Klinika Nowotworow Gornego Odcinka Uklad Digestii, Oncology Center - Institute (Warsaw, Poland)