Mięsak gladkokomórkowy macicy – problemy diagnostyczne. Przegląd literatury


Author(s): Dorota TeresiÅ?ska, Wieslawa Bednarek, Agnieszka Puchalska-Kosiecz, Marcin BobiÅ?ski, Maria Mazurkiewicz

The aim of the study is to present the current state of knowledge on uterine leiomyosarcomas, with particular consideration of the role of proteins - p53, Ki-67, survivin, bax, and caspases - in these neoplasms. Leiomyosarcomas are rare neoplasms of the reproductive organs; still, they result in a considerably high mortality rate. Moreover, that type of neoplasms poses high diagnostic difficulties in clinical practice. Those features of leiomyosarcomas are stimuli for seeking new paths in their diagnosing as well as in therapy. In the recent years, an increasing importance has been attached to molecular studies focusing on an analysis of the role of proteins participating in cell proliferation (e.g. Ki-67) and controlling the mechanisms of apoptosis (caspases, p53, survivin, bax). The results of the studies are very promising and inspiring with hope for a quick development of clinical oncology.

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Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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