Mangosteen (Garcinia mangostana): Compositional profile and usage in cancer molecular docking studies


Author(s): Jaideep Mahendra, Vivek Sharma, Little Mahendra, Janani M, Sajid. T. Hussain, Sunitha Janarthan, Pavithra H Dave

Background: Primitive medicinal plants and dietary variables have received increased attention in the hunt for novel compounds with possibly promising anti-cancer action. A wide range of natural compounds has been studied as chemopreventive or therapeutic agents. Indeed, paclitaxel, etoposide, camptothecin, and vincristine have all been utilized as anti-cancer medicines. Aim: This literature review was collected from the web sources such as PubMed, Science Direct and Elsevier publications which summarizes the evidence of its properties and supports the case for future studies to assess the utility of Mangosteen pericarp as an adjunctive treatment option for cancer-related effects. Review Results: Recent studies revealed that these xanthones which are isolated from the tree not only exhibited a variety of anti-inflammatory, anti-bacterial but also has anti-cancer effects. Garcinia mangostana is a tropical tree where the pericarp of Mangosteen fruit, for ages has been used as a medicinal ingredient in the treatment of various diseases due to its extraordinary anti-oxidant and anti-bacterial activities. Conclusion: The results collected from numerous cancer cell lines, chemicallyinduced tumours and implanted tumours in animal models, as presented in the review, demonstrated that Mangosteen herb may effectively suppress the process of carcinogenesis with a pleiotropic mechanism of action.

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Editors List


    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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