Żóltakogwiaździak wielopostaciowy: obraz kliniczny, leczenie, rokowanie. Przegląd literatury

Abstract

Author(s): Anna Mucha-Malecka, Bogdan GliÅ?ski, Krzysztof Malecki1, Krzysztof Roszkowski, Marta UrbaÅ?ska-GÄ?siorowska

Pleomorphic xanthoastrocytoma (PXA) is a superficial, circumscribed rare glial tumor with the typical location in the cerebral hemispheres, particularly in the temporal and parietal lobes. Microscopic features include marked cellular pleomorphism, nuclear atypia, increased mitotic index and presence of necrosis. It affects children and young adults, and has a relatively favorable prognosis with ten-years relapse- free survival, and overall survival of 61% and 70% respectively. Surgery remains the mainstay of treatment, the roles of adjuvant irradiation and chemotherapy remains undefined. Radiotherapy with total doses of 30-60 Gy, delivered in the conventional fractionation regimen is recommended after subtotal resection, and in patients who have anaplastic variant of PXA. Extent of resection, the value of mitotic index and presence of necrosis are the recognized factors influencing clinical outcome.

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Editors List

  • S.SREEDHAR

    Submitted PhD thesis in Biotechnology at GITAM University, Vizag.

  • Yousef Alomi

    Yousef Alomi
    The Past Head, General Administration of Pharmaceutical Care at Ministry of Health,
    Saudi Arabia Critical Care/TPN
    Clinical Pharmacist Ministry of Health,
    Riyadh, Saudi Arabia.

  • Osamu Tanaka

    Osamu Tanaka
    Assistant Professor,
    Department of Radiation Oncology
    Asahi University Hospital
    Gifu city, Gifu, Japan

  • Maher Abdel Fattah Al-Shayeb

    Department of Surgical Sciences, Ajman University, UAE

  • Andrzej Zdziennicki

    Institute of Gynecology and Obstetrics, Medical University of Lodz, I Clinic of Gynecology and Gynecological Oncology (Lodz, Poland)

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